天津中医药2017，Vol.34Issue(10)：703-708,6.DOI:10.11656/j.issn.1672-1519.2017.10.17
几种辅料对葛根素液晶纳米粒粒径、电位、包封率的影响
Effect of several materials on the particle size, Zeta potential and encapsulation efficiency of Pue-LCN
摘要
Abstract
[Objective] To identify the effect of several materials (oleic acid,sodium oleate,octadecylamine, vitamin E acetate, tween 80) on the particle size, Zeta potential and encapsulation efficiency of puerarin liquid crystalline nanoparticles (Pue-LCN) and select the most proper material to improve the stability of Pue-LCN. [Methods] Pue-LCN was investigated by thin film-dispersion method. The particle size, zeta potential, pH and encapsulation efficiency were used as indexes to select the most suitable stabilizer, and identify the effect the stabilizer on the stability of Pue-LCN. [Results] Vitamin E acetate is the most suitable stabilizer of liquid crystalline nanoparticles, the particle size radius of the preparation was (94.62± 3.18) nm, and the potential was (-37.47±1.550) mV. The system pH was 8.70. The encapsulation efficiency reached 92.14%±0.3827%, and week encapsulation rate could be maintained more than 90%. [Conclusion] Vitamin E acetate can significantly improve the stability of liquid crystal nanoparticles. The preparation has good dispersion of nanoparticles and particle size uniformity.关键词
液晶纳米粒/包封率/粒径/Zeta电位/稳定性Key words
liquid crystalline nanoparticle/encapsulation efficiency/particle size/Zeta potential/stability分类
医药卫生引用本文复制引用
谭宁,杜守颖,薛宇涛,马军明,陆洋,李鹏跃..几种辅料对葛根素液晶纳米粒粒径、电位、包封率的影响[J].天津中医药,2017,34(10):703-708,6.基金项目
北京市自然科学基金项目(7164274) （7164274）
北京中医药大学青年骨干教师课题(2015-JYB-QNJSZX002). （2015-JYB-QNJSZX002）
