西安交通大学学报（医学版）2017，Vol.38Issue(6)：892-897,6.DOI:10.7652/jdyxb201706021
双示踪剂PET成像在阿尔茨海默病诊断中的价值
Diagnostic value of dual-tracer PET imaging in Alzheimer's disease
摘要
Abstract
Objective To investigate the diagnostic value of dual-tracer PET imaging in Alzheimer's disease (AD).Methods For this study,we enrolled 11 patients who were diagnosed clinically with AD and 7 age-matched healthy controls who underwent 11 C-PIB and 18 F-FDG PET brain imaging in the same period.Visual evaluation was used to observe the distribution of tracers.ROI technology and brain metabolism analysis software were used to quantify the uptake levels of PIB and FDG.Results Compared with that in HC group,FDG imaging pattern in AD group was presented as focal hypometabolism in posterior cingutate,superior frontal lobe,inferior frontal lobe, superior parietal lobe and lateral temporal lobe.PIB retention was mainly in bilateral superior frontal lobe,inferior frontal lobe,superior parietal lobe,lateral temporal lobe and posterior cingulate gyrus in images of equilibrium phase.The two FDG imaging results were basically in agreement with each other.Conclusion PIB with combined FDG PET imaging can provide more accurate information in diagnosis of AD.Further study is needed to confirm the effectiveness and practicability of this technology.关键词
阿尔茨海默病/正电子发射计算机断层/18F标记脱氧葡萄糖/11C标记匹兹堡化合物/诊断Key words
Alzheimer's disease/positron emission tomography/18 F-deoxyglucose/11 C-Pittsburgh compound B/diagnosis分类
医药卫生引用本文复制引用
段小艺,刘翔,李淼,郭佑民..双示踪剂PET成像在阿尔茨海默病诊断中的价值[J].西安交通大学学报（医学版）,2017,38(6):892-897,6.基金项目
西安交通大学第一附属医院临床研究面上项目(No.XJTU1AF-CRF-2015-013) Supported by the Clinical Research Fund of the First Affiliated Hospital,Xi'an Jiaotong University (No.XJTU1AF-CRF-2015-013). （No.XJTU1AF-CRF-2015-013）
