西安交通大学学报（医学版）2017，Vol.38Issue(6)：904-907,920,5.DOI:10.7652/jdyxb201706023
Clusterin、E-cadherin在宫颈鳞癌组织中的表达及其相关性分析
Expressions of Clusterin and E-cadherin in cervical squamous carcinoma and their correlation
刘娟 1冀静 2邢兰英3
作者信息
- 1. 西安交通大学第二附属医院妇产科,陕西西安 710003
- 2. 西北妇女儿童医院妇产科,陕西西安 710061
- 3. 西安交通大学第一附属医院妇产科,陕西西安 710003
- 折叠
摘要
Abstract
Objective To explore the expressions of clusterin and E-cadherin in cervical squamous tissues and their correlation.Methods Immunohistochemical technique was used to measure the expressions of clusterin and E-cadherin in 18 normal cervical tissues,32 cervical intraepithelial neoplasia (CIN)tissues and 40 cervical squamous carcinoma (CSC)tissues.Results There were on significant differences in baseline characteristics among the three groups based on standardized differences.The expressions of clusterin in CSC,CIN2 and CIN3 tissues were significantly higher than those in normal cervical tissues (P <0.05 ).The expression of clusterin was significantly lower in grade Ⅰ than in grade Ⅲ (P <0.01)and was connected with clinical stage (P <0.05 )instead of lymph node metastasis and cancer stromal invasion depth (P > 0.05 ).The expressions of E-cadherin in tissues of CSC, CIN2 and CIN3 were significantly lower than those in normal cervical tissues (P <0.05).E-cadherin expression was both significantly higher in grade Ⅰ and grade Ⅱ than in grade Ⅲ (P <0.05),and was associated with lymph node metastasis (P < 0.05 )rather than clinical stage and cancer stromal invasion depth (P > 0.05 ).A negative correlation was found between the expressions of clusterin and E-cadherin in CSC (r = - 0.339,P < 0.05 ). Conclusion The significantly different expressions of clusterin and E-cadherin may be related to the development of CSC,suggesting that the two may be used as potential markers for early diagnosis of CSC.关键词
宫颈鳞癌/宫颈上皮内瘤变/E-cadherin/Clusterin/免疫组织化学染色Key words
cervical squamous carcinoma/cervical intraepithelial neoplasia (CIN)/E-cadherin/clusterin/immunohistochemistry分类
医药卫生引用本文复制引用
刘娟,冀静,邢兰英..Clusterin、E-cadherin在宫颈鳞癌组织中的表达及其相关性分析[J].西安交通大学学报（医学版）,2017,38(6):904-907,920,5.
