西北国防医学杂志2017，Vol.38Issue(9)：579-582,4.DOI:10.16021/j.cnki.1007-8622.2017.09.005
探讨YKL-40在肝硬变中的诊断价值及其与肝硬变患者肝功能和现有肝纤维化指标的相关性
Diagnostic value of YKL-40 and correlation with liver function and liver fibrosis indexes in patients with liver cirrhosis
摘要
Abstract
Objective:To evaluate the serum level of YKL-40 in patients with hepatocellular carcinoma (HCC) and liver cirrhosis (LC),and its diagnosis values of LC.Methods:A total of 397 individuals enrolled in our study were divided into HCC group (n =171),LC group (n =112) and healthy control group (n =114).The serum level of YKL-40 were tested based on Enzyme-linked immunosorbent assay (ELISA) kit.Diagnostic value of YKL-40 and correlation with liver function and liver fibrosis indexes in patients with liver cirrhosis were analyzed.Results:The serum level of YKL-40 in LC group was statistically significant higher than that of HCC group and healthy control group (P ＜ 0.01).Compared with the healthy control group,ROC curve was used to analyze the diagnosis value of YKL-40 in LC,the area under the curve of LC group was 0.934 (95％ confidence interval:0.904-0.964).When the cutoff value of YKL-40 was 92.25 ng/ml,the sensitivity was 81.3％,and the specificity was 90.4％.The level of YKL-40 was positively correlated with Child-Pugh stage and the FIB-4 index.Conclusion:YKL-40 is highly expressed in patients with LC and HCC which might be a helpful marker in the diagnosis of LC and judgement the severity of LC.关键词
原发性肝癌/肝硬变/YKL-40Key words
hepatocellular carcinoma/liver cirrhosis/YKL-40分类
医药卫生引用本文复制引用
于瑞淼..探讨YKL-40在肝硬变中的诊断价值及其与肝硬变患者肝功能和现有肝纤维化指标的相关性[J].西北国防医学杂志,2017,38(9):579-582,4.
