现代妇产科进展2017，Vol.26Issue(10)：760-762,3.DOI:10.13283/j.cnki.xdfckjz.2017.10.006
ICP与妊娠期CHB伴胆汁酸升高的围产结局比较26
Comparison of perinatal outcome between ICP and chronic hepatitis B with elevated ser-um total bile acid during pregnancy
摘要
Abstract
Objective:To explore the differences of biochemical indicators and preg-nancy outcomes between ICP and chronic hepatitis B with elevated serum total bile acid during pregnancy . Methods:A retrospective analysis of patients was performed on the data of 262 preg-nant women who had their prenatal examinations and delivered in Shanghai Public Health Clini-cal Center from Dec. 2013 to Nov. 2015. They were divided into two groups:intrahepatic chole-stasis of pregnancy group ( ICP) (116 cases) ,and chronic hepatitis B group ( CHB) with ele-vated serum total bile acid( TBA) (146 cases) . Results:No significant difference was found in the liver function indicators between the two groups when the TBA was in the peak level. After treatment,TBA and transaminase significantly decreased in both groups. The level of transami-nase in ICP group was still higher than that of CHB group(P<0. 05). The rate of fetal distress, meconium stained amniotic fluid( MSAF) ,incidence of premature delivery,asphyxia of newborn ( Apgar score in 1 and 5 minute) had statistically significant difference between the two groups (P<0. 05). In ICP group,the rate of LGA was significantly higher than that of CHB group ( 9 . 84% vs 2 . 1%) . Conclusions:ICP and pregnancy with CHB will be significantly improved after active treatment. In the disease observation of simple ICP,both bile acid and transaminases levels should be paid high attention. In CHB pregnant women, if there is a good treatment effect,the gestational age can be extended under closely monitoring.关键词
妊娠期肝内胆汁淤积症/慢性乙型肝炎/总胆汁酸/围产结局Key words
Intrahepatic cholestasis of pregnancy/Chronic Hepatitis B/Total bile acid/Perinatal outcome分类
医药卫生引用本文复制引用
杨杰莲,刘敏..ICP与妊娠期CHB伴胆汁酸升高的围产结局比较26[J].现代妇产科进展,2017,26(10):760-762,3.基金项目
上海市卫计委面上项目资助(No:201540179) （No:201540179）
