西南国防医药2017，Vol.27Issue(10)：1046-1049,4.DOI:10.3969/j.issn.1004-0188.2017.10.004
EBP50在胰腺癌中的表达及其临床意义
Expression and clinical significance of EBP50 in pancreatic cancer
摘要
Abstract
Objective To explore the expression and clinical significance of EBP50 in pancreatic cancer.Methods Real-time PCR was adopted for detecting the levels of EBP50 mRNA in 20 pancreatic cancer and its adjacent tissues and 10 normal pancreas tissues,quantum dot technology was adopted for detecting the expression of EBP50 protein in 120 pancreatic cancer and its adjacent tissues and 10 normal pancreas tissues,and the five-year survival rate of 120 patients with pancreatic cancer was analyzed.Resuts The expression rate of EBP50 mRNA and protein in pancreatic cancer tissues was significantly lower than that in adjacent noncancerous tissue and normal pancreatic tissues;the expression rate of EBP50 mRNA and protein in adjacent tissues was also lower than that in normal pancreatic tissues (P ＜ 0.05);the prognostic survival period of pancreatic cancer patients with higher expression of EBP50 was significantly longer than that with low expression (P ＜ 0.05).Conclusion The low expression of EBP50 in pancreatic cancer indicates that it is a cancer suppressor gene,can be used as the new target for treating pancreatic cancer and is worthy of in-depth study.关键词
胰腺癌/EBP50基因/表达/预后Key words
pancreatic cancer/, EBP50 gene/expression/prognosis分类
医药卫生引用本文复制引用
季梦遥,袁磊,董卫国..EBP50在胰腺癌中的表达及其临床意义[J].西南国防医药,2017,27(10):1046-1049,4.基金项目
武汉大学自主科研项目(2042015kf0071,2042016kf0081) （2042015kf0071,2042016kf0081）
