西南国防医药2017，Vol.27Issue(10)：1052-1055,4.DOI:10.3969/j.issn.1004-0188.2017.10.006
改良型富血小板纤维蛋白修复兔颅骨缺损的影像学分析
Effects of A-PRF in repair of rabbit skull defects
摘要
Abstract
Objective To observe the effects of advanced platelet-rich fibrin (A-PRF) in the repair of rabbit skull defects and evaluate of the ability of A-PRF in order to induce bone tissue defect repair and regeneration.Methos A total of 30 healthy male Japanese big-eared rabbits were selected and randomly divided into an A-PRF group and a blank group (n=15,respectively).Two circular piercing bone defects with a diameter of 6.0 mm were created on the parietal bone of rabbits.The defects in the A-PRF group were filled with A-PRF for repair and those in the blank group with nothing.Three experimental animals in each group were killed right after two weeks,four weeks,eight weeks and twelve weeks after the operation respectively.The repair and regeneration of bone tissue were examined and observed by X rays.Results The bone density resistance projection and bone healing rate two weeks,four weeks,eight weeks and 12 weeks after the operation were significantly better or higher than those in the blank group (P ＜ 0.05).Canclusion A-PRF can promote the healing of bone defect and the formation of new bone.关键词
A-PRF/骨缺损修复/临界性骨缺损/X线Key words
A-PRF/bone defect repair/, critical-size bone defect/X ray分类
医药卫生引用本文复制引用
闵昌琴,付冬梅,芦帅,孙嵩,李德华,孙勇..改良型富血小板纤维蛋白修复兔颅骨缺损的影像学分析[J].西南国防医药,2017,27(10):1052-1055,4.基金项目
成都军区机关医院立项课题(Y201601) （Y201601）
军事口腔医学国家重点实验室资助课题(2016KB01) （2016KB01）
