摘要
Abstract
Objective To study the effects of perindopril on cognitive function and renal function in the patients with hypertension complicated with mild cognitive impairment (MCI).Methods A total of 186 patients with essential hypertension (EH) complicated with MCI to receive treatment in our hospital were selected and randomly divided into a control group and a combination group (n =93,respectively).The control group was treated with levamlodipine and the combination group with levamlodipine + perindopril for six months.The effects between the two groups were compared.Results The overall response rate (ORR) in the combination group (94.62％) was significantly higher than that in the control group (83.87％) (P ＜ 0.05);after the treatment,the blood pressure (BP) in the two groups decreased significantly (P ＜ 0.05);the aggregate scores of the mini mental status examination (MMSE),memory,immediate memory,orientation,language ability,attention and calculative ability were improved remarkably (P ＜ 0.05);the levels of blood urea nitrogen (BUN),serum creatinine (Scr),24 h urine protein in the two groups decreased significantly (P ＜ 0.05);creatinine clearance rate (Ccr) and glomerular filtration rate (GFR) levels increased greatly,while the improvement of them was greater than that in the control group (P ＜ 0.05);the adverse reaction rate in the combination group was 7.53％ and that in the control group was 6.45％,showing no statistical difference (P ＞ 0.05).Conclusion Perindopril can significantly improve the effects in the treatment of EH complicated with MCI,improve the cognitive competence and renal function of patients and has high safety.关键词
高血压/认知功能障碍/培哚普利/肾功能/疗效Key words
hypertension/cognition impairment/perindopril/renal function/effect分类
医药卫生
