西南国防医药2017，Vol.27Issue(10)：1068-1071,4.DOI:10.3969/j.issn.1004-0188.2017.10.012
肾炎舒联合氯沙坦对早期DN患者尿足细胞及炎症因子的影响
Effects of ShenYanShu combined with losartan on urinary podocyte and inflammatory factors in patients with early DN
杨薪博 1吴洁琼 1孙杰1
作者信息
- 1. 712083陕西咸阳,陕西中医药大学第二附属医院脾胃肾病科
- 折叠
摘要
Abstract
Objective To explore the effects of ShenYanShuKeLi combined with losartan on urinary podocyte and inflammatory factors in the patients with early diabetic nephropathy (DN).Methos A total of 85 patients with DN to receive treatment in our hospital were selected and randomly divided in a control group (n=43) and an observation group (n=42).On the basis of conventional treatment,the control group was treated with losartan and the observation group with ShenYanShuKeLi combined with losartan.The changes in the serum creatinine (Scr),adiponectin (APN),urinary podocyte relevant indexes and the levels of inflammatory factors before and after the treatment between the two groups were compared.Results After the treatment,the levels of Scr and APN in the two groups improved significantly (P ＜ 0.05);neutrophilgelatinase associated lipocalin (NGAL),N-acetyl-β-D-glucosaminidase (NAG) and urinary albumin/creatinine ratio (ACR) decreased significantly;the levels of interleukin-6 (IL-6),tumor necrosis factor-or (TNF-α),high-sensitivity C-reactive protein (hs-CRP) decreased significantly;the improvement of the above indexes was significant greater than that in the control group (P ＜ 0.05).Conchusion ShenYanShuKeLi combined with losartan can effectively protect the renal function of patients and relieve renal injury,and obviously inhibit inflammatory response in the treatment of early DN.关键词
糖尿病肾病/肾炎舒颗粒/氯沙坦/尿足细胞/炎症因子Key words
DN/ShenYanShuKeLi/losartan/urinary podocyte/inflammatory factor分类
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杨薪博,吴洁琼,孙杰..肾炎舒联合氯沙坦对早期DN患者尿足细胞及炎症因子的影响[J].西南国防医药,2017,27(10):1068-1071,4.
