首页|期刊导航|药物分析学报（英文）|Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
药物分析学报（英文）2017，Vol.7Issue(5)：324-331,8.
Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
摘要
Abstract
A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10–7.50 μmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.关键词
Graphene quantum dots/One-step synthesis/Fluorescence quenching/Penicillamine/Pharmaceutical preparationsKey words
Graphene quantum dots/One-step synthesis/Fluorescence quenching/Penicillamine/Pharmaceutical preparations引用本文复制引用
..[J].药物分析学报（英文）,2017,7(5):324-331,8.基金项目
This work was partially supported by the NIH–Research Centers at Minority Institutions (G12MD007591), and the projects CTQ2016- 78793-P (MINECO of Spain) and PEIC-2014-001-P (Junta de Comunidades de Castilla-La Mancha, JCCM). Gema M. Durán thanks to MINECO of Spain for the predoctoral (BES-2011-045438) and stay (EEBB-I-15-10091) grants. （G12MD007591）
