中风与神经疾病杂志2017，Vol.34Issue(10)：893-896,4.
甘草甜素对癫痫持续状态大鼠神经保护作用及机制研究
Protective effects and mechanism of glycyrrhizin on status epilepticus rats
摘要
Abstract
Objective To study the protective effects and mechanism of glycyrrhizin on neuronal damage of Status Epilepticus(SE)rathippocampus.Methods 60 healthy adult male Sprague-Dawley rats were included in thisstudy.SE rat model were induced by intraperitoneally injected with lithium and pilocarpine method .All rats were randomly divided in-to three groups:(SE+GL)-treated group,(SE+S) group and normal control group.According to different GL dosage,(SE+GL)-treated group were divided into three subgroup:high glycyrrhizin group ( HGL, 20 mg/kg ) , middle glycyrrhizin group (MGL,10 mg/kg),low glycyrrhizin group (LGL,5 mg/kg).The hippocampal neuronal damage was detected by nissl's staining,levels of HMGB1 in serum and hippocampus were determined with enzyme linked immunosorbent assay ( ELISA) and western blot .Results Compared with those in ( SE+S) group,the cortical neurons damage significantly re-duced and HMGB1 expressions were significantly decreased in (SE+GL)-treated group (P<0.05).Conclusion GL sig-nificantly decreased neuronal damage in the cortex of SE rat models ,and it turned out dose-dependent .These results suggest that GL affords neuroprotective effects in lithium-pilocarpine induced SE rats ,which may via inhibiting the expressions of HMGB1 in serum and cortical neurons .关键词
癫痫持续状态/甘草甜素/大脑皮质神经元/HMGB1Key words
Status epilepticus/Glycyrrhizin/Cortical neuron/HMGB1分类
临床医学引用本文复制引用
王林,李亚军,张蓓,常明则,石少亭,张世俊,折潇,杨春梅..甘草甜素对癫痫持续状态大鼠神经保护作用及机制研究[J].中风与神经疾病杂志,2017,34(10):893-896,4.基金项目
陕西省科技统筹创新工程计划(No.S2015TLSF0010) （No.S2015TLSF0010）
陕西省教育厅基金( No.11JK0715 ) （ No.11JK0715 ）
陕西省卫生厅科研基金( No. 2012D43) （ No. 2012D43）
