中国肺癌杂志2017，Vol.20Issue(10)：667-674,8.DOI:10.3779/j.issn.1009-3419.2017.10.02
30例双原发肺癌的临床及预后因素分析
Clinical and Prognosic Anylasis of 30 Cases with Double Primary Lung Cancer
王子奇 1侯晶晶 2王慧娟 1张国伟 1马智勇1
作者信息
- 1. 450008 郑州,郑州大学附属肿瘤医院呼吸内科
- 2. 454150 焦作,焦作市第二人民医院肿瘤内科一病区
- 折叠
摘要
Abstract
Background and objective Multiple primary lung cancer (MPLC) represents a rare variety of pulmonary malignant tumor while mainly consist of double primary lung cancer (DPLC), but the development of diag-nostic techniques promotes the rate diagnosis of it in recent years. Here we summarize and anylasis the data of 30 cases with DPLC in expectation of improving congnitive of MPLC. Methods We retrospectly studied 30 MPLC patients who diagnosed from January 2010 to December 2015 in Affiliated Cancer Hospital of Zhengzhou University. The clini-cal characteristics, diagnosis, therapeutic methods and prognosis were analyzed. Results Among 30 patients enrolled, metachronous DPLC (27/30, 90%) is far more common than synchronous DPLC. The majority of the lesions located at right upper lobe (20/60, 33.3%), and adenocarcinoma (25/60, 41.7%) turns out to be the major pathological pat-ter. Patients with same pathological pattern of two lesions of DPLC (17/30, 56.7%) were slightly more than those with different pattern(13/30,43.3%)and adeno-adeno was the most common pattern in the former ones.Cox regression anylasis shows that lymphatic metastasis (HR=4.349, 95%CI: 1.435-13.178, P=0.009) and experience of heavy smok-ing (HR=2.996, 95%CI: 1.089-8.240, P=0.034) were associate with worse prognosis. Conclusion DPLC are mainly located at right upper lobe, and mostly adenocarcinomas. Earlier diagnosis, active therapeutic approaches and a strict smoking cessation strategy may improve the prognosis of MPLC.关键词
肺肿瘤/多原发肺癌/双原发肺癌/临床特征/治疗/预后Key words
Lung neoplasms/Multiple primary lung cancer/Double Primary Lung Cancer/Clinical features/Treatment/Prognosis引用本文复制引用
王子奇,侯晶晶,王慧娟,张国伟,马智勇..30例双原发肺癌的临床及预后因素分析[J].中国肺癌杂志,2017,20(10):667-674,8.
