中国肺癌杂志2017，Vol.20Issue(10)：715-719,5.DOI:10.3779/j.issn.1009-3419.2017.10.09
肺癌PDTX模型的研究进展
Advances in Patient Derived Tumor Xenograft (PDTX) Model from Lung Cancer
摘要
Abstract
With the development of tumor molecular biology and genomics, it has been recognized that there are great heterogeneity in the biological characteristics, molecular typing and reactivity of the same tumor species among different individuals. In order to achieve true tumor individualized and precise therapy, a new concept of human tumor tissue xenograftmodel (patient derived tumor xenograft, PDTX) is proposed. The previous study has revealed that PDTX model can truly reflect the biological characteristics of tumor tissue and drug efficacy. And PDTX model could be used to select individual che-motherapy regime, evaluate drug resistance and explore efficacy and safety of new drug. PDTX model has been used in clinical practice of several type of cancer including lung cancer. In this paper, the current research progress of lung cancer PDTX is reviewed.关键词
肺肿瘤/PDTX模型/精准治疗Key words
Lung neoplasms/Patient derived tumor xenograft/Precision therapy引用本文复制引用
秦保东,焦晓栋,原凌燕,柳珂,臧远胜..肺癌PDTX模型的研究进展[J].中国肺癌杂志,2017,20(10):715-719,5.基金项目
本研究受上海市青年科技扬帆计划(No.17YF1425200)、上海长征医院青年启动基金(No.2015CZQN07)、国家自然科学基金(No.81702249)以及上海市卫生计生委基金(No.201540174)资助 This paper was supported by the grants from Shanghai Sailing Program (to Baodong QIN)(No.17YF1425200),the Young Start-up Foundation of Changzheng Hospital (to Xiaodong JIAO)(No.2015CZQN07), National Nature Science Foundation of China (to Baodong QIN)(No.81702249), Shanghai Municipal Health and Family Planning Commission Foundation (to Xiaodong JIAO)(No.201540174). （No.17YF1425200）
