中国全科医学2017，Vol.20Issue(25)：3132-3135,4.DOI:10.3969/j.issn.1007-9572.2017.25.014
多靶点粪便基因检测在社区结直肠癌筛查中的应用价值研究
Values of Multi-target Stool DNA Test for Community-based Colorectal Cancer Screening
摘要
Abstract
Objective To explore the values of multi-target stool DNA test for community-based colorectal cancer (CRC) screening.Methods We conducted a CRC screening in Lujiazui Community,Sanlin Community,and Yingbo Community located in Pudong New Area,Shanghai between August 2014 and July 2016 by a survey with Colorectal Cancer Risk Assessment Scale for Community-dwelling Residents in Shanghai (CCRASCRS) and two rounds of fecal occult blood testing (FOBT).The assessment results of CCRASCRS,and one or two rounds of FOBT results were positive in 294 cases (experimental group),and those of CCRASCRS and the two rounds of FOBT results were negative in 102 cases (control group).Two weeks later,all of them successively underwent multi-target stool DNA test for detecting aberrantly methylated BMP3 and NDRG4 promoter regions and mutant KRAS,colonoscopy and colorectal biopsy in Dongfang Hospital Affiliated to Tongji University.The diagnostic value of multi-target stool DNA test was assessed by the gold standard for diagnosis,the results of colonoscopy and pathological examination of colorectal biopsy specimens.Results For diagnosing CRC,colorectal precancerous lesion in the experimental group,the sensitivity of multi-target stool DNA test were respectively 85.7％ [95％ CI (59.8％,100.0％)],75.0％ [95％ CI (32.6％,100.0％)].For diagnosing the common colorectal polyps and identifying thc residents without any colorectal lesions,the specificity of multi-target stool DNA test was 84.0％ [95％ CI (79.7％,88.3％)] for the experimental group,and 83.8％ [95％ CI (76.7％,89.2％)] for the control group.Conclusion Combined use of multi-target stool DNA test and FOBT can improve the accuracy of community-based CRC screening.关键词
结直肠肿瘤/粪便/基因检测/结肠镜检查/潜血试验/筛查Key words
Colorectal neoplasms/Feces/Genetic testing/Colonoscopy/Occult blood testing/Screening分类
医药卫生引用本文复制引用
彭晨,蒋小华,姜景蔚,郑萍..多靶点粪便基因检测在社区结直肠癌筛查中的应用价值研究[J].中国全科医学,2017,20(25):3132-3135,4.基金项目
浦东新区科技发展基金创新资金(医疗卫生)项目(PKJ2014-Y39) （医疗卫生）
