中国实验动物学报2017，Vol.25Issue(5)：473-478,6.DOI:10.3969/j.issn.1005-4847.2017.05.002
PCOS易感基因Hmga2在小鼠子宫蜕膜化中的表达与调节
Expression and regulation of PCOS susceptible gene Hmga2 in mouse uterine decidualization
摘要
Abstract
Objective To study the expression and regulation of polycystic ovary syndrome ( PCOS) susceptibility gene Hmga2 in endometrial receptivity and decidualization. Methods Experiments including early pregnancy, delayed implantation and activation, artificial decidualization and ovarian steroid hormone treatment were performed, and Q-PCR and Western blot analyses were applied to explain the role of Hmga2 in endometrial receptivity. Results The Hmga2 ex-pression increased gradually with pregnancy. Its expression at the implantation site was significantly higher than that at the inter-implantation site,in the embryo activation group than in delayed implantation group, and in the artificial decidualiza-tion than the non-decidualization. The expression of Hmga2 was positively correlated with the expression of estrogen and progesterone, and was positively regulated by estrogen and progesterone in vivo. Conclusions Our findings indicate that the expression of Hmga2 is closely related to the embryo implantation process in early pregnancy in mice, is involved in the process of endometrial decidualization, and is influenced by the activated blastocyst and steroid hormones.关键词
多囊卵巢综合征/高迁移率族蛋白A2/蜕膜化/胚胎/小鼠Key words
Polycystic ovary syndrome/PCOS/Hmga2/Decidualization/Embryos/Mouse分类
生物科学引用本文复制引用
曹永芝,赵跃然,林德贵..PCOS易感基因Hmga2在小鼠子宫蜕膜化中的表达与调节[J].中国实验动物学报,2017,25(5):473-478,6.基金项目
国家自然科学基金项目(编号:31572578). （编号:31572578）
