中国比较医学杂志2017，Vol.27Issue(10)：47-50,4.DOI:10.3969.j.issn.1671-7856.2017.10.009
松花粉辅助紫杉醇联合铂类化疗的增效减毒作用
Synergism and attenuation effects of Pini Pollen on paclitaxel and cisplatine chemotherapy
摘要
Abstract
Objective To investigate the synergism and attenuation effects of Pini Pollen on paclitaxel and cisplatin ( TP) chemotherapy in model mice. Methods Forty-eight model nude mice with H456 cell line xenograft were divided into 8 groups: model group, TP chemotherapy group, Pini Pollen (150, 300 and 600 mg/kg) group and TP chemotherapy plus Pini Pollen (150, 300 and 600 mg/kg) group. The tumor inhibition rates, body weight, food intake, hematology and blood biochemistry indexes were selected to evaluate the synergism and attenuation effects of intragastric administration of Pini Pollen (150,300,600 mg/kg) on TP chemotherapy. Results Compared with the TP chemotherapy group, the tumor inhibition rates, body weight, food intake, white blood cell count were increased and liver and kidney function damage were alleviated significantly in the TP chemotherapy plus Pini Pollen groups. Conclusions Pini Pollen has a significant synergism and attenuation effects on TP chemotherapy.关键词
松花粉/增效/减毒/肺癌Key words
Pini Pollen/Synergism/Attenuation/Lung Cancer分类
医药卫生引用本文复制引用
赵学友,巩萍,孙铜,马玉奎..松花粉辅助紫杉醇联合铂类化疗的增效减毒作用[J].中国比较医学杂志,2017,27(10):47-50,4.基金项目
山东省自主创新及成果转化专项(2014ZZCX02104). （2014ZZCX02104）
