中国比较医学杂志2017，Vol.27Issue(10)：89-95,7.DOI:10.3969.j.issn.1671-7856.2017.10.018
肌萎缩侧索硬化症相关基因突变与疾病动物模型
Amyotrophic lateral sclerosis-associated gene mutations and ALS animal models
摘要
Abstract
Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons that lead to paralysis and even death. Mutations in a large number of genes, including FUS/TLS, EPHA4, SS18 L1, ATXN2 and C9ORF72, are identified to the casual genes of ALS, which broadens our understanding of the role of RNA modulation in ALS pathogenesis. This review summarized ALS-associated genes and the related ALS rodent models.关键词
肌萎缩侧索硬化症/基因突变/动物模型Key words
Amyotrophic lateral sclerosis/Gene mutation/Animal model分类
医药卫生引用本文复制引用
张丽,张连峰..肌萎缩侧索硬化症相关基因突变与疾病动物模型[J].中国比较医学杂志,2017,27(10):89-95,7.基金项目
国家自然科学基金(81571222) （81571222）
中央级公益科研院所基本科研业务费(2016ZX310039). （2016ZX310039）
