中国比较医学杂志2017，Vol.27Issue(10)：113-119,7.DOI:10.3969.j.issn.1671-7856.2017.10.022
免疫系统人源化小鼠模型的研究进展
Research progress of humanized mouse models in immune system
连晶瑶 1丁苗慧 2秦国慧 3张毅 1王纯耀1
作者信息
- 1. 郑州大学第一附属医院,郑州 450052
- 2. 郑州大学,郑州 450052
- 3. 郑州大学临床医学系,郑州 450052
- 折叠
摘要
Abstract
Animal model is an animal material with human mimic performance established in biomedical scientific research. It can be used as experimental basis for studies of experimental hypothesis and clinical hypothesis. It can shorten the research time and observe the whole process of disease occurrence, development or prevention and treatment. Human biomedical research is largely limited by the biological complexity. In order to overcome this limitation, based on the immunosuppressive characteristics of a severely immunodeficient ( SCID) or recombinant activated gene ( Ragnul ) in mice, humanized mouse models of human diseases can be established and have been widely used to study the underlying principles of human immunobiology and complex pathological mechanisms of human diseases. This approach has become one of the important ways to promote the development of medical sciences, with practicality and foresight. In this paper, the application and research progress of humanized mouse models are reviewed.关键词
动物模型/人源化小鼠/治疗/进展Key words
Humanized mouse models/Human diseases分类
医药卫生引用本文复制引用
连晶瑶,丁苗慧,秦国慧,张毅,王纯耀..免疫系统人源化小鼠模型的研究进展[J].中国比较医学杂志,2017,27(10):113-119,7.
