中国比较医学杂志2017，Vol.27Issue(10)：123-126,4.DOI:10.3969.j.issn.1671-7856.2017.10.024
基因突变动物模型在《医学遗传学》实验教学中的应用
Application of mutated inbred animal models in the experimental teaching of medical genetics
摘要
Abstract
Objective Mutated inbred animal model is introduced to the practical course of genetic diagnosis in the hope that medical students are able to apply what they have learned to clinical cases, based on a deep understanding of principle and technology on gene mutation detection. Methods We integrated DNA extraction, polymerase chain reaction, agarose gel electrophoresis, and gel imaging analysis into a comprehensive experiment and arranged 4-year-programme undergraduates majoring in preclinical medical sciences to conduct it with the purpose of investigating the internal relations between phenotype and genotype in a hairless Uncv mouse model. Subsequently, the questionnaire aimed at evaluating learning effect on the part of students was handed out and their feedbacks were analyzed. Results More than 90% of respondents are satisfied with the general learning effect. Especially, 98. 7% of students support the enhancing effect of the new teaching mode on their research skills and 96% consider the practical course helpful to their problem-solving ability. Conclusions The introduction of mutated inbred animal model to the practical system of molecular diagnostics proves beneficial to boost students' learning effect and scientific research quality. Our practice also provokes thoughts on the further utilization of animal models in teaching system of medical sciences.关键词
基因突变动物模型/实验课教学/分子遗传诊断Key words
Mutated animal model/Experimental teaching/Molecular genetic diagnostics分类
医药卫生引用本文复制引用
唐佐青,霍学云,韩玉英,王晶,叶海虹,赵天,李振坤,陈振文..基因突变动物模型在《医学遗传学》实验教学中的应用[J].中国比较医学杂志,2017,27(10):123-126,4.基金项目
2016年度首都医科大学校长基金(2016JYY01). （2016JYY01）
