中国实用口腔科杂志2017，Vol.10Issue(9)：554-557,4.DOI:10.19538/j.kq.2017.09.010
牙本质基质蛋白-1参与下颌功能前伸过程中髁突软骨增殖的实验研究
Study on the condylar cartilage proliferation participated by DMP-1 in the process of mandibular functional protrusion
摘要
Abstract
Objective Objective To investigate the changes in the expression of DMP-1 in the condylar of a young rat during functional mandibular protrusion.This work also explores the function of DMP-1 in the cartilage proliferation,which provides experimental evidence for the clinical orthopedic treatment for bone type Ⅱ malocclusion.Methods Totally 70 healthy male Sprague-Dawleys (SD) rats at the age of 4 weeks were included in the study.The rats were divided randomly and equally into experimental group and control group.The mandibular protrusion bite plate appliances that were fitted to the animals in the experimental group were worn all day.No operation was performed in the control group.Five rats were executed in each group after 1,3,7,14,21,28 and 35d.Detect the expression and variation of DMP-1 by immunohistochemical method and cell image analysis system.Results On the 3rd day,the expression of DMP-1 in condylar cartilage was obviously enhanced in the experimental group.which reached to the highest level on the 14th day,IHS=85.67±4.51,which had significant difference (P ＜ 0.05) compared with control group,IHS=10.67± 1.53.Conclusion DMP-1 participates in condylar cartilage adaptive remodeling during the process of mandibular protrusion of rats,and promotes condylar cartilage proliferation and endochondral ossification.关键词
下颌功能前伸/髁突软骨/骨改建/DMP-1Key words
mandibular functional protrusion/condylar cartilage/bone remodeling/DMP-1分类
医药卫生引用本文复制引用
汪浩然,左艳萍,闫宝勇,马素伟,李爽..牙本质基质蛋白-1参与下颌功能前伸过程中髁突软骨增殖的实验研究[J].中国实用口腔科杂志,2017,10(9):554-557,4.基金项目
河北省卫计委医学科学研究课题计划(20160712) （20160712）
