中国现代医学杂志2017，Vol.27Issue(24)：39-43,5.DOI:10.3969/j.issn.1005-8982.2017.24.008
食管癌患者miR-182表达水平及其对预后的影响
Expression of miRNA-182 and its effect on prognosis of esophageal carcinoma
鲁之中 1李军民 1胡云芝 2李晓辉 3李卫 1姜富国 1李帅 1申辰1
作者信息
- 1. 河南省焦作市人民医院 检验科,河南 焦作 454002
- 2. 河南省焦作市人民医院 儿科,河南 焦作 454002
- 3. 河南省焦作市人民医院 肿瘤外科,河南 焦作 454002
- 折叠
摘要
Abstract
Objective To investigate the concentration of miRNA-182 in esophageal carcinoma and its association with disease prognosis. Methods MicroRNA-182 in 59 esophageal carcinoma tissues and related adjacent healthy tissues were measured by quantitative real time polymerase chain reaction (qRT-PCT). Association of miRNA-182 with clinical characters including pathologic types, and clinical outcome was determined. Results The concentration of miRNA-182 in esophageal carcinoma tissues was significantly increased when compared with that in adjacent healthy tissues ( P< 0.05). Overexpression of miRNA-182 correlated closely with tumor differentiation level, depth of infiltration, metastasis, and clinical stage ( P<0.05). Kaplan-Meier survival analysis indicated that patients with high miRNA-182 experienced worse outcome compared with others ( P<0.05). Moreover, multivariate analysis showed that increase of miRNA-182 was an independent predictor of overall survival ( P<0.05). Conclusions MicroRNA-182 is overexpressed in esophageal carcinoma tissue and concentration of miRNA-182 is closely correlated with poor outcome, suggesting that miRNA-182 may serve as a prognostic biomarker for esophageal carcinoma.关键词
miR-182/食管癌/预后/实时荧光定量PCRKey words
miRNA-182/esophageal carcinoma/prognosis factor/qRT-PCR分类
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鲁之中,李军民,胡云芝,李晓辉,李卫,姜富国,李帅,申辰..食管癌患者miR-182表达水平及其对预后的影响[J].中国现代医学杂志,2017,27(24):39-43,5.
