中国药房2017，Vol.28Issue(29)：4042-4045,4.DOI:10.6039/j.issn.1001-0408.2017.29.03
3种药物预防胃肠道肿瘤患者化疗致肝损伤的临床观察和经济学评价
Clinical Observation and Economic Evaluation of 3 Kinds of Drugs Preventing Chemotherapy-induced Liv-er Damage in Patients with Gastrointestinal Tumors
摘要
Abstract
OBJECTIVE:To observe the preventive effects and safety of 3 kinds of drugs on chemotherapy-induced liver dam-age in patients with gastrointestinal tumors,and to evaluate economics. METHODS:A total of 128 patients with gastrointestinal malignant tumor and systemic chemotherapy indication selected from our hospital during 2014-2015 were divided into group A(42 cases),B(46 cases)and C(40 cases)according to random number table. Since the first day of chemotherapy,group A,B and C were given Reduced glutathione for injection(1.2 g),Magnesium isoglycyrrhizinate injection(100 mg)and Polyene phosphati-dylcholine injection(465 mg)for preventing chemotherapy-induced liver damage respectively,for 7 d. The preventive effects and ADR occurrence were observed in 3 groups,and the economic analysis was conducted. RESULTS:Total response rates of group A,B and C were 90.48%,97.83% and 87.50%,and that of group B was significantly higher than other 2 groups,with statistical significance(P<0.05). But there was no statistical significance between group A and C(P>0.05). The costs of group A,B and C were 1 465.86,1 518.94,1 554.04 yuan,and cost-minimization analysis was adopted to evaluate the plans of group A and C. The plan of group A was more economical. Cost-effectiveness analysis was used to evaluate the plans of group A and B,cost-effectiveness ratio of group A and B were 1 620.09 and 1 552.63;incremental cost-effectiveness ratio was 722.18, and the plan of group B was more economical. The above conclusion was supported by the results of sensitivity analysis. Three patients in group B suffered from transient elevated blood pressure and then recovered 2-3 d after drug withdrawal. CONCLU-SIONS:The preventive effects and economics of Magnesium isoglycyrrhizinate injection is better than Reduced glutathione for injection and Polyene phosphatidylcholine injection for chemotherapy-induced liver damage in patients with gastrointestinal tu-mors. The blood pressure of patients should be monitored closely during application. Reduced glutathione for injection is more suitable for patients with primary hypertensive disease.关键词
药物性肝损伤/注射用还原型谷胱甘肽/异甘草酸镁注射液/多烯磷脂酰胆碱注射液/胃肠道肿瘤/药物经济学Key words
Drug-induced liver damage/Reduced glutathione for injection/Magnesium isoglycyrrhizinate injection/Polyene phosphatidylcholine injection/Gastrointestinal tumor/Pharmacoeconomics分类
医药卫生引用本文复制引用
李琴,李玲..3种药物预防胃肠道肿瘤患者化疗致肝损伤的临床观察和经济学评价[J].中国药房,2017,28(29):4042-4045,4.基金项目
上海市药学会医院药学科研项目(No.2015-YY-01-18) （No.2015-YY-01-18）
