中国药房2017，Vol.28Issue(29)：4080-4085,6.DOI:10.6039/j.issn.1001-0408.2017.29.13
2011-2016年我院1775株血流感染病原菌构成及其耐药性分析
Distribution of 1 775 Strains of Bloodstream Infection Pathogens and Analysis of Drug Resistance in Our Hospital during 2011-2016
方平安 1陈科帆 1易斌 1曾瑜 1李佳萌 1熊域皎 1袁术生1
作者信息
- 1. 乐山市人民医院感染科,四川乐山614000
- 折叠
摘要
Abstract
OBJECTIVE:To provide reference for rational use of antibiotics in the clinic. METHODS:Blood culture positive specimens were collected from our hospital during Jan. 2011-Dec.2016. Distribution of bloodstream infection(BSI)pathogens and drug resistance were analyzed in our hospital retrospectively. RESULTS:During 2011-2016,26 034 blood culture specimens isolat-ed from inpatients of our hospital were examined,including 1 775 positive specimens with positive rate of 6.82%. The specimens mainly came from tumor hematology department(10.65%),neurosurgery department(8.28%)and pediatric department(8.00%). A total of 1 775 strains of pathogens were detected,including 967 strains of Gram-negative bacteria(54.48%)mainly as Escherich-ia coli,Klebsiella pneumoniae,649 strains of Gram-positive bacteria(36.56%)mainly as Coagulase negative Staphylococci, Staphylococcus aureus and 159 strains of fungus(8.96%)mainly as Candida albicans. E. coli and K. pneumoniae were resistant to common antibiotics to different extents,but sensitive to piperacillin sodium and tazobactam sodium,imipenem,meropenem. Aci-netobacter baumanii was highly resistant to enzyme inhibitors,cephalosporins,aminoglycosides,quinolones. Pseudomonas aerugi-nosa was sensitive to third-generation cephalosporins,aminoglycosides and quinolones. S. aureus was highly resistant to penicil-lins,cephalosporins and aminoglycosides. Resistance rate of Coagulase negative Staphylococci to most commonly used antibiotics was higher than 40%. Above two bacteria were sensitive to linezolid and vancomycin with resistance rate of 0. A total of 205 strains of ESBLs-producing E. coli(42.01%),64 strains of ESBLs-producing K. pneumoniae(30.33%)and 31 strains of Methicil-lin-resistant S.aureus(17.61%)were detected.No vancomycin-resistant Enterococcus or vancomycin-resistant S.aureus was detect-ed. CONCLUSIONS:BSI pathogens mainly distribute in tumor hematology department of our hospital. BSI pathogens mainly in-clude Enterobacteriaceae and Staphylococcus,and also involve fungus. The situation of drug resistance and enzyme production are not optimistic.Antibiotics,which are sensitive to the major pathogens,include carbapenems,linezolid and vancomycin.关键词
血流感染/血培养/病原菌/分布/耐药性Key words
Bloodstream infection/Blood culture/Pathogens/Distribution/Drug resistance分类
医药卫生引用本文复制引用
方平安,陈科帆,易斌,曾瑜,李佳萌,熊域皎,袁术生..2011-2016年我院1775株血流感染病原菌构成及其耐药性分析[J].中国药房,2017,28(29):4080-4085,6.
