中国中医药信息杂志2017，Vol.24Issue(11)：53-57,5.DOI:10.3969/j.issn.1005-5304.2017.11.013
按经选穴针刺对失眠大鼠下丘脑-垂体-肾上腺皮质轴相关激素的影响
Effects of Acupuncture Treatment on HPA Axis Related Hormones in Insomnia Rats
摘要
Abstract
Objective To observe the effects of acupuncture treatment on the levels of HPA axis related hormones and acupoint compatibility in insomnia rats; To discuss the mechanism of action for acupuncture treatment. Methods Chlorophenylalanine suspension was under intraperitoneal injection to establish insomnia model rats. Sixty SD rats were randomly divided into blank group, model group, Baihui+Shenmen group, Baihui+Sanyinjiao group, Baihui+non-acupoint group, with 12 rats in each group. Each treatment group received acupuncture in relevant acupoints, 30 min each time, for 7 d. ELISA was used to measure the levels of CRH, ACTH and CORT. Results Compared with the model group, the levels of CRH, ACTH and CORT of the acupuncture groups decreased to some extent. In the three acupuncture groups, the efficacy of Baihui+Shenmen group was better than that of Baihui+Sanyinjiao group and Baihui+non-non-acupoint group. Conclusion Acupuncture treatment may calm and soothe the nerves to release the insomnia through regulating HPA axis related hormones. Acupuncture acupoints at different meridians may be one of the factors that cause the difference of acupoints compatibility effect.关键词
针刺/失眠/下丘脑-垂体-肾上腺皮质轴/按经选穴/腧穴配伍/大鼠Key words
acupuncture/insomnia/HPA axis/acupoints at different meridians/acupoints compatibility/rats分类
医药卫生引用本文复制引用
吴雪芬,岳增辉,郑雪娜,郭鑫,谢志强,谢莉娜..按经选穴针刺对失眠大鼠下丘脑-垂体-肾上腺皮质轴相关激素的影响[J].中国中医药信息杂志,2017,24(11):53-57,5.基金项目
国家重点基础研究发展计划(2014CB543102) （2014CB543102）
国家自然科学基金(81673886) （81673886）
