中国中医药信息杂志2017，Vol.24Issue(11)：96-100,5.DOI:10.3969/j.issn.1005-5304.2017.11.023
榄香烯联合放疗干预肺癌脑转移系统评价
Systematic Evaluation of Elemene Combined with Radiotherapy for Intervention in Brain Metastasis from Pulmonary Neoplasms
摘要
Abstract
Objective To systematically evaluate the effectiveness and safety of Elemene combined with radiotherapy for intervention in brain metastasis from pulmonary neoplasms. Methods Articles of clinical randomized controlled trials about Elemene combined with radiotherapy for intervention in brain metastasis from pulmonary neoplasms from the establishment of the databases to October of 2016 from CNKI, CBM, Chongqing Weipu, Wanfang database, Cochrane Library, PubMed and Embase were retrieved by computers. Bias risk assessment tools in Cochrane systematic evaluation handbook 5.1.0 was used to conduct quality evaluation for included articles. RevMan5.3 software was used to carry out Meta-analysis. Results Totally 12 articles and 839 patients were included. Results of Meta-analysis showed that Elemene combined with radiotherapy had more obvious curative effect on narrowing the neoplasm compared with pure radiotherapy [OR=2.73, 95%CI (1.97, 3.77), P<0.000 01], and improve patients' life quality at the same time [OR=3.85, 95%CI (2.23, 6.65), P<0.000 01], and relieve adverse reactions [OR=4.16, 95%CI (2.40, 7.22), P<0.000 01]. Conclusion Elemene combined with radiotherapy for intervention in brain metastasis from pulmonary neoplasms shows confirmed efficacy, and is relatively safe. But whether the program should be widely used in clinic, more large sample, multi-center, and high-quality clinical randomized controlled trials are still needed.关键词
榄香烯/肺癌/脑转移/放疗/系统评价Key words
Elemene/pulmonary neoplasms/brain metastasis/radiotherapy/systematic assessment分类
医药卫生引用本文复制引用
池志恒,虞舜,温雯婷..榄香烯联合放疗干预肺癌脑转移系统评价[J].中国中医药信息杂志,2017,24(11):96-100,5.基金项目
江苏省优势学科建设工程项目(2016年) （2016年）
江苏省中医药防治肿瘤协同创新中心课题(012092002005) （012092002005）
