中成药2017，Vol.39Issue(10)：2009-2014,6.DOI:10.3969/j.issn.1001-1528.2017.10.004
麻黄对甘草3个成分血药浓度的影响
Effects of Ephedrae Herba on plasma levels of three constituents in Glycyrrhizae Radix et Rhizoma
摘要
Abstract
AIM To investigate the effects of the compatibility of Ephedrae Herba (Mahuang) and Glycyrrhizae Radix et Rhizoma (Gancao) on pharmacokinetic changes of the plasma levels of glycyrrhizic acid,glycyrrhetinic acid and liquiritin by UPLC-MS/MS.METHODS Twelve SD rats were randomly divided into two groups and orally administered with Glycyrrhizae Radix et Rhizoma and Ephedrae Herba-Glycyrrhizae Radix et Rhizoma (2 ∶ 1) Decoction.Blood samples were collected at different time points,and the main pharmacokinetic parameters were calculated by DAS3.2.2 software.RESULTS Compared with Glycyrrhizae Radix et Rhizoma group,the AUC0-t and Cmax were decreased,the MRT0-t and t1/2z were extended,the Vz/F was increased for glycyrrhizic acid,glycyrrhetinic acid and liquiritin;the CLz/F was increased for glycyrrhizic acid and liquiritin;the Tmax of glycyrrhizic acid was shortened and the Tmax of glycyrrhetinic acid was extended.CONCLUSION After combining Glycyrrhizae Radix et Rhizoma and Ephedrae Herba,the bioavailability of glycyrrhizic acid,glycyrrhetinic acid and liquiritin are reduced,the elimination of them delays,and the distribution volume increases.关键词
麻黄/甘草/药对/甘草酸/甘草次酸/甘草苷/药动学Key words
Ephedrae Herba (Mahuang)/Glycyrrhizae Radix et Rhizoma (Gancao)/herbal pair/glycyrrhizic acid/glycyrrhetinic acid/liquiritin/pharmacokinetics分类
医药卫生引用本文复制引用
卫平,马钦海,任孟月,罗佳波..麻黄对甘草3个成分血药浓度的影响[J].中成药,2017,39(10):2009-2014,6.基金项目
国家自然科学基金重点项目(81030066) （81030066）
深圳市坪山新区卫生系统科研资助项目(201538) （201538）
