中成药2017，Vol.39Issue(10)：2014-2017,4.DOI:10.3969/j.issn.1001-1528.2017.10.005
鸢尾苷元在兔体内的药动学
Pharmacokinetics of tectorigenin in rabbit
摘要
Abstract
AIM To develop a HPLC method for determining tectorigenin content in rabbit plasma for pharmacokinetics.METHODS As self crossover control,the rabbits,six Japanese giant ear rabbits were subject to a singledose intragastric administration of 60 mg/kg (tectorigenin 40 mg/kg) pueraria isoflavone.The free and enzymatic tectorigenin contents in plasma were measured by HPLC,and then pharmacokinetic parameters were calculated by PKsolver 2.0 pharmacokinetic program.RESULTS The AUC0-t,Tmax,Cmax after intragastric administration of pueraria isoflavone were (46.78 ±5.12) μg · min/mL,(5.39 ±0.54) min,(0.84 ±0.21) μg/mL for free tectorigenin,respectively;(485.48 ±23.53) μg · min/mL,(20.12 ±2.84) min,(2.95 ±0.67) μg/mL for total tectorigenin,respectively.CONCLUSION HPLC method is suitable for tectorigenin pharmacokinetic study.Tectorigenin is present mainly as glucuronide conjugates in plasma after intragastric administration pueraria isoflavone.关键词
葛花异黄酮/鸢尾苷元/HPLC/药动学Key words
pueraria isoflavone/tectorigenin/HPLC/pharmacokinetics分类
医药卫生引用本文复制引用
王金凤,赵庆兰,王芳,魏颖,赵楠,刘丹,王国玉..鸢尾苷元在兔体内的药动学[J].中成药,2017,39(10):2014-2017,4.基金项目
吉林省科技发展计划项目(20140204040YY) （20140204040YY）
