中成药2017，Vol.39Issue(10)：2029-2033,5.DOI:10.3969/j.issn.1001-1528.2017.10.008
陈氏清肺方治疗类风湿关节炎合并肺间质病变的临床疗效
Clinical efficacy of Chenshi Qingfei Decoction on rheumatoid arthritis and interstitial lung disease
摘要
Abstract
AIM To explore the efficacy of Chenshi Qingfei Decoction (Pseudostellariae Radix,Ophiopogonis Radix,Adenophorae Radix,etc.) against rheumatoid arthritis and interstitial lung disease (RA-ILD).METHODS Based on Prednisolone,RA-ILD patients were randomly divided into control group and observation group by random number table and randomized block design.The observation group took Chenshi Qingfei Decoction.The treatment course was three months for both groups.Before the treatment,the activity of the disease (DAS28) was assessed and ESR,CRP,RF,CCP were measured.Before and after the treatment,high resolution-CT (HRCT) was conducted and graded,and symptoms and signs were graded.RESULTS After the treatment,the effective rate of cough,expectoration and breath hard in the syndromes of Chinese traditional medicine was 71％ in the observation group and 23％ in the control group (P ＜0.01).The effective rate of improved lung imaging by HRCT was 68％ in the observation group but 13％ in the control group (P ＜0.01).CONCLUSION Based on the immunosuppressive agents therapy in RA,Chenshi Qingfei Decoction can relieve clinical symptoms of cough,expectoration and breath hard,and reduce area and degree of interstitial lung disease by HRCT.关键词
类风湿关节炎(RA)/肺间质病变(ILD)/陈氏清肺方/高分辨CT (HRCT)Key words
rheumatoid arthritis (RA)/interstitial lung disease (ILD)/Chenshi Qingfei Decoction/high-resolution computed tomography (HRCT)分类
医药卫生引用本文复制引用
唐小蓉,沈杰,何东仪,朱琦,岳涛,姜婷,汪荣盛,刘秀华,孙红梅..陈氏清肺方治疗类风湿关节炎合并肺间质病变的临床疗效[J].中成药,2017,39(10):2029-2033,5.基金项目
上海市长宁区卫生和计划生育委员会科研基金(CNKW2013J05) （CNKW2013J05）
