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短柱八角化学成分及其抗炎活性的研究

叶全知黄豆豆陈伟吕闪闪孙连娜

中成药2017，Vol.39Issue(10)：2081-2085,5.

中成药2017，Vol.39Issue(10)：2081-2085,5.DOI:10.3969/j.issn.1001-1528.2017.10.019

短柱八角化学成分及其抗炎活性的研究

Chemical constituents from Illicium brevistylum and their anti-inflammatory activities

叶全知 ¹黄豆豆 ²陈伟 ³吕闪闪 ⁴孙连娜¹

作者信息

1. 福建中医药大学药学院,福建福州350108
2. 第二军医大学药学院,上海200433
3. 菏泽家政职业技术学院,山东菏泽274300
4. 宜春学院,江西宜春336000
折叠

摘要

Abstract

AIM To study the chemical constituents from Illicium brevistylum A.C.Smith and to evaluate their anti-inflammatory activities.METHODS The n-BuOH fraction of 80％ ethanol extract from I.brevistylum was isolated and purified by silica,ODS and Sephadex LH-20,the structures of obtained compounds were identified by spectral data.Then their anti-inflammatory activities were screened.RESULTS Nine compounds were isolated and identified as (7S,8R)-3,3',5-trimethoxy-4',7-epoxy-8,5'-neolignan-4,9,9'-triol (1),methylabieta-8,11,13,15-tetraen-18-oate (2),majusanin A (3),pubeside C (4),(+)-lyoniresinol-3a-O-α-L-rhamnopyranoside (5),junipercomnoside D (6),lyoniside (7),nudiposide (8),rhyncoside A (9).The inhibition rates of compounds 2,6,9 on NF-κB were 47.81％,37.33％,33.37％,respectively.CONCLUSION Compounds 1,5,7-9 are isolated from genus Illicium for the first time,and compounds 2,6,9 exhibit good anti-inflammatory activities.

关键词

短柱八角/化学成分/分离鉴定/抗炎活性/NF-κB

Key words

Illicium brevistylum A.C.Smith/chemical constituents/isolation and identification/anti-inflammatory activities/NF-κB

分类

医药卫生

引用本文复制引用

叶全知,黄豆豆,陈伟,吕闪闪,孙连娜..短柱八角化学成分及其抗炎活性的研究[J].中成药,2017,39(10):2081-2085,5.

中成药

OA北大核心CSCDCSTPCD

ISSN：1001-1528

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