浙江医学2017，Vol.39Issue(17)：1433-1435,1439,4.DOI:10.12056/j.issn.1006-2785.2017.39.17.2017-676
过夜配戴角膜塑型镜对睑板腺与泪膜脂质层厚度的影响
Influence of overnight orthokeratology lens wearing on meibomian glands and tear film lipid layer
陈思萍 1陈茹茹 1陈岩1
作者信息
- 1. 310020 温州医科大学附属眼视光医院杭州院区眼视光专科
- 折叠
摘要
Abstract
Objective To evaluate the influence of overnight orthokeratology (OK) lens wearing on Meibomian glands and the tear film lipid layer.Methods One hundred myopic patients (100 eyes) wearing overnight OK lens for ＞1 year (overnight OK lens group) and another 100 myopic patients (100 eyes) wearing normal glasses (control group) were enrolled in the study.Tear-film lipid layer thickness (LLT),blinking frequency and partial blinking were measured by the LipiView interferometer.The lower lid tear meniscus height,noninvasive tear break-up time (NI-BUT) and the structure of the Meibomian glands were assessed by Keratograph 5,the defect area percentage of Meibomian glands on the upper eyelid were calculated.The fundamental secretion of tears was measured.Covariance analysis,independent-samples T test,Mann-Whitney U tests,and multivariate regression were used in analyzing the data.Results The NI-BUT was 7.83(5.27,14.09) s and 5.68 (4.03,13.01) s in control group and the NI-BUT was significantly longer in the overnight OK lens group than that in control group (P＜0.05).The defect area percentage of Meibomian glands on the upper eyelid was 14.38％ ± 7.09％ and 13.30％ ± 6.67％ in overnight OK lens group and control group,respectively(P＞0.05).Tear-film lipid layer thickness was 57.97 ± 18.59 nm and 56.61 ± 20.67 nm in two groups,respectively(P＞0.05).There were no statistical significances in fundamental secretion of tears,the lower lid tear meniscus height,blinking frequency and partial blinking between two groups (P ＞0.05).The defect area percentage of Meibomian glands on the upper eyelid decreased as the lower lid tear meniscus height increasing and the lipid layer thickness of tear film had a positive correlation with NI-BUT.Conclusion The overnight OK lens wearing is relatively safe,and the baseline state of Meibomian gland should be taken into account in the prescription of orthokeratology lenses.关键词
角膜塑型镜/泪膜/睑板腺/泪膜脂质层厚度Key words
Orthokeratology/Tear film/Meibomian gland/Tear-film lipid layer thickness引用本文复制引用
陈思萍,陈茹茹,陈岩..过夜配戴角膜塑型镜对睑板腺与泪膜脂质层厚度的影响[J].浙江医学,2017,39(17):1433-1435,1439,4.
