浙江医学2017，Vol.39Issue(17)：1440-1444,5.DOI:10.12056/j.issn.1006-2785.2017.39.17.2016-557
甲状腺激素联合B型脑钠肽检测对急性心力衰竭患者预后的影响
Prognosis value of thyroxin with B-type natriuretic peptide for patients with acute heart failure
摘要
Abstract
Objective To assess the prognostic value of thyroxin combined with B-type natriuretic peptide (BNP) in patients with acute heart failure(AHF).Methods A total of 619 AHF patients were included in this study.Thyroid hormone profile,BNP were measured within 24h after admission.The patients were divided into survival group and non-survival group.Using Cox hazards model,receiver operating characteristic curve and Kaplan-Meier survival analysis,the correlation of thyroid hormone levels and BNP with all-cause mortalities of patients was assessed.Results The incidence of low triiodothyronine syndrome (LT3S) in patients with AHF was 44.4％.At the median follow-up time of 19 ± 13 months,204 patients (32.9％) were died.Multivariate Cox regression analysis showed that age (HR=1.033,95％ CI:1.017-1.049,P＜0.01),FT3 (HR=0.489,95％ CI:0.384-0.628,P＜0.01),BNP (HR=2.136,95％ CI:1.114-4.126,P＜0.01) and serum creatinine (HR=1.002,95％CI:1.001-1.003,P＜0.05) were independent predictors for all-cause mortality.Based on the cut-off value of FT3(≤ 2.72 pmol/L) and BNP(＞2 230 pg/ml),Kaplan-Meier analysis provided the significant prognostic information with the highest risk of all-cause death (HR=7.247,95％CI:3.993-13.152,P＜0.01) in the low FT3 (≤2.72 pmol/L)/high BNP (＞2 230pg/ml) group.Conclusion FT3 levels appear to be independent predictor for all-cause mortalities among AHF patients,and low FT3 and high BNP levels predicts a worse long-term outcome.关键词
急性心力衰竭/游离三碘甲状腺原氨酸/B型脑钠肽/预后Key words
Acute heart failure/Free triiodothyronin/B-type natriuretic peptides/Prognosis引用本文复制引用
全军民,潘金安,姚琪,陶袁,邱樑,周林丽,陈浩,俞林,吕峰,曲迪..甲状腺激素联合B型脑钠肽检测对急性心力衰竭患者预后的影响[J].浙江医学,2017,39(17):1440-1444,5.基金项目
绍兴市卫生计生科技计划项目(2016CX027) （2016CX027）
