组织工程与重建外科杂志2017，Vol.13Issue(4)：215-219,5.DOI:10.3969/j.issn.1673-0364.2017.04.011
颅缝早闭症与FGF信号通路
Craniosynostosis and FGF Signaling Pathway
摘要
Abstract
Craniosynostosis represents a kind of skull deformity caused by the premature fusion of one or more cranial sutures,which often changes the patient's appearance,sometimes obstructs the normal development.Although the exact pathogenesis of early cranial suture closure is still largely unknown,the fibroblast epidermal growth factor (FGF) seems to have affected the normal development of the cranial sutures.In this paper,the recent genetic researches related craniosynostosis and those identified pathogenic genes were summarized,mainly focuses on the FGF factors,to help the genetic diagnosis and the study of cranial sutures defects.关键词
颅缝早闭症/致病基因/遗传模式/成纤维表皮生长因子Key words
Craniosynostosis/Pathogenic genes/Inheritance pattern/Fibroblast growth factors分类
医药卫生引用本文复制引用
李国清,寇瑶,程铭津,徐胜,田静..颅缝早闭症与FGF信号通路[J].组织工程与重建外科杂志,2017,13(4):215-219,5.基金项目
西部资源生物与现代生物技术教育部重点实验室开放基金项目(360011326). （360011326）
