结直肠肛门外科2017，Vol.23Issue(4)：440-444,5.
CD68+、CD163+巨噬细胞在结直肠癌组织中的浸润及意义
The infiltration and significance of CD68+ and CD163+ macrophages in colorectal carcinoma
何岸江 1胡卫军 2李霄 1张卓超 2王菲 2易钢锋1
作者信息
- 1. 西安市第一医院普通外科 陕西西安 710002
- 2. 西京医院肝胆胰脾外科 陕西西安 710032
- 折叠
摘要
Abstract
Objective To compare the relationship between CD68+ and CD163+ macrophages in colorectal cancer (CRC) and its relationship with clinicopathological parameters.Methods Immunohistochemical method was used to detect 68 cases of resected colorectal cancer tissue microarray,and the number of CD68+ and CD163+ macrophages was calculated.According to the dyeing results,the 68 samples were divided into high and low expression group of macrophages in CD68+ and CD163+,and then the chnical pathological features of CRC and the correlation were analyzed.Results The expression of CD68+,CD163+ macrophages in CRC tissues in higher than the corresponding paracancerous tissue,and the expression of CD68+ macrophages in cancer tissues was higher than that in CD163+ macrophages(P ＜ 0.05).Meanwhile,compared with the low expression group,the high expression group of CD68+ macrophage in cancer tissues showed significant difference in lymph node metastasis and TNM staging (P ＜ 0.05).The high expression of CD163+ macrophage in carcinoma group with lymph node metastasis was significantly higher than the low expression group (P ＜ 0.05).Regression analysis showed that TNM stage is an independent risk factor for expression of CD68+ macrophage CRC carcinoma and lymph node metastasis is the independent risk factors of CD163+ macrophage expression of macrophage CRC carcinoma.Conclusion The presence of CD68+ and CD163+ macrophage in CRC tissue macrophages is closely related with TNM staging which is strongly correlated with lymph node metastasis,which may provide a reference for clinical on colorectal cancer progression and prognosis.关键词
结直肠癌/CD68+/CD163+/肿瘤相关巨噬细胞/免疫组化Key words
colorectal cancer/CD68+/CD163+/tumor associated macrophages/immunohistochemistry分类
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何岸江,胡卫军,李霄,张卓超,王菲,易钢锋..CD68+、CD163+巨噬细胞在结直肠癌组织中的浸润及意义[J].结直肠肛门外科,2017,23(4):440-444,5.
