摘要
Abstract
Objective To investigate the correlation between 64-multidetector-row CT (64MDCT) perfusion imaging parameters and the microvessel density (MVD) in colorectal cancer.Methods 32 cases with colorectal cancer treated in our hospital from January 2016 to January 2017 were selected.The blood flow (BF),blood volume (BV),time to start (TTS),time to peak (TTP) and permeability surface area product (PS) were obtained by 64MDCT perfusion imaging,the MVD were observed by postoperative immunohistochemical staining.The relationship between the above indexes and Dukers staging and differentiation were evaluated,the correlation between 64MDCT indexes and MVD were analyzed.The patients were followed up until June 2017.Patients with cancer death,recurrence and metastasis were assigned to the poor prognosis group,the rest were the good prognosis group.BF,BV,TTS,TTP,PS and MVD between the two groups were compared.Results BF was (56.0±27.4) mL· 100g-1·min-1,BV was (44.5±24.2) mL· 100g-1,TTS was (27.0±10.2) s,TTP was (95.0±30.0) s,PS was (5.4±2.6) ×10-1·mL· 100g-1·min-1,MVD was (32.7±11.1)/high power field in the patients.BF,TTS,TTP,PS and MVD were not significantly correlated with Dukes staging and differentiation (all P ＞ 0.05),while BV were significantly correlated with Dukes stage of the tumor (P ＜ 0.05).BF,BV,TTS,TIP,PS and MVD in the poor prognosis group were significantly higher (P＜ 0.05).BF,BV,TTS and PS were positively correlated with MVD (r =0.645,0.493,0.504,and 0.632;all P ＜ 0.01).Conclusion CT perfusion imaging parameters can reflect the microvessel density of colorectal cancer,which may be helpful to evaluate the invasion and metastasis of tumor,while the parameters rarely has correlations with tumor stages and differentiation.关键词
CT灌注成像/64排螺旋CT/结直肠癌/微血管密度Key words
CT perfusion imaging/64-multi-detector-row CT/colorectal cancer/microvessel density分类
医药卫生
