摘要
Abstract
Objective To observe the effect of dexmedetomidine on the recovery of sevoflurane inhalation after general anesthesia.Methods 94 patients with colorectal cancer were selected and randomly divided into the observation group and control group with 47 cases in each group.according to the random number table,The patients in the two groups underwent laparoscopic radical resection of colorectal cancer,the observation group was treated with dexmedetomidine after general anesthesia and the control group was given 0.9％ sodium chloride injection.The HR,MAP,mental function and the incidence of restlessness during anesthesia recovery were compared between two groups,including the time before anesthesia induction(T1）,before operation (T2),30 min after opreation(T3),1 h after operation (T4),the end of operation (T5),before extubation (T6) and immediately after extubation (T7).Results There were no significant difference between HR and MAP at T1～T5 moment in two groups (P ＞ 0.05).The HR [(80.64±5.14)times/min,(83.13±5.50)times/min] and MAP [(97.88±5.33)mmHg,(102.00±5.80)mmHg] at T6 and T7 moment in the observation group were lower than the control group [(87.34±5.66)times/min,(90.22±6.01)times/min],[(102.71 ±4.60) mmHg,(107.84±6.31) mmHg] (P ＜ 0.05).There were no obvious difference in the scores of physiology,emotion and cognitive function between the two groups (P ＞ 0.05).There were no evident changes in the scores of the observation group at 30 min after operation (P ＞ 0.05),while the scores of physiology,cognition and function were decreased and the scores of emotion were increased (P ＜ 0.05).The physiological and cognitive and functional scores in observation group [(25.27± 1.62) points,(22.14±3.55) points] were significantly higher than the control group [(22.62±2.01)points and (18.96±3.42)points],and the emotional score [(2.82±0.74)points] was lower than the control group [(3.54±0.83)points](P ＜ 0.05).The incidence of restlessness in the anesthesia group was 19.15％,which was lower than that in the control group (38.30％,P ＜ 0.05).Conclusion In the laparoscopic radical resection of colorectal cancer,continuous intravenous intravenous injection of dexmedetomidine was more conducive to maintaining stable hemodynamics,avoid postoperative mental disorders,improve the quality of anesthesia recovery and reduce the recovery period of restlessness.关键词
右美托咪定/结直肠癌根治术/血流动力学/麻醉复苏/躁动Key words
Dexmedetomidine/colorectal cancer radical resection/hemodynamics/anesthesia recovery/restlessness分类
医药卫生
