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三维有序孔道结构的壳聚糖/二氧化硅复合骨架材料的研究

解玉玲 陈嘉曦 吴都督 李宝红

硅酸盐通报2017,Vol.36Issue(9):3159-3162,3179,5.
硅酸盐通报2017,Vol.36Issue(9):3159-3162,3179,5.

三维有序孔道结构的壳聚糖/二氧化硅复合骨架材料的研究

Chitosan/Silica Composite Framework Materials with Three Dimensionally Ordered Porous Structure

解玉玲 1陈嘉曦 1吴都督 1李宝红1

作者信息

  • 1. 广东医科大学药学院,东莞 523808
  • 折叠

摘要

Abstract

3D-CS/Si composite framework materials with three dimensionally ordered porous structure were prepared using colloid crystal as template .The physicochemical property was characterized by SEM , FT-IR, TGA and XRD.Nimodipine ( NMDP) was incorporated into the porous channel as a model drug . It showes that the combination of silica significantly improves the mechanical stability of the polymer matrix successfully .And there are hydrogen bonds between silica and chitosan .The mass ratio of chitosan in the composite matrices is 23.40%.The matrix showes amorphous state .As drug carrier, it showes a high drug loading and enhances drug release .

关键词

胶体晶体模板法/壳聚糖/二氧化硅/复合骨架材料

Key words

colloid crystal template/CS/Si/composite framework material

分类

医药卫生

引用本文复制引用

解玉玲,陈嘉曦,吴都督,李宝红..三维有序孔道结构的壳聚糖/二氧化硅复合骨架材料的研究[J].硅酸盐通报,2017,36(9):3159-3162,3179,5.

基金项目

广东医科大学科研基金( M2016017 ) ( M2016017 )

硅酸盐通报

OA北大核心CSCDCSTPCD

1001-1625

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