国际妇产科学杂志2017，Vol.44Issue(5)：494-498,5.
p38MAPK信号传导通路与卵巢癌关系研究进展
Progress of Relationship between p38MAPK Pathway and Ovarian Carcinoma
摘要
Abstract
Mitogen-activated protein kinases (MAPK) is a class of serine/threonine protein kinase. This cascade existed broadly in mammalian cells. The subfamily includes extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38MAPK. It is a significant signaling pathway to deliver extracellular signals into nucleus, involved in the important mechanisms of cell growth and proliferation. Recently studies found that function of p38MAPK, mediating many cell reactions induced by stress, inflammatory cytokines or bacterial products and changing the level of gene expression through phosphorylation of transcription factor and play an important role in cell functions, involved in the process of oophoroma cells apoptosis, invasion, metastasis and drug resistance. Therefore, the clarification of mechanism of p38MAPK pathway will provide new thoughts and methods for diagnosis and treatment of ovarian cancer. This review summarizes the function of p38MAPK signal transduction pathway in ovarian cancer, and the p38MAPK related research progress of new drugs and drug resistance.关键词
p38丝裂原活化蛋白激酶类/信号传导/信号通路/卵巢肿瘤/抗药性,肿瘤Key words
p38 mitogen -activated protein kinase/Signal transduction/Signal pathway/Ovarian neoplasms/Drug resistance,neoplasm引用本文复制引用
龙玲,周琦,张笠..p38MAPK信号传导通路与卵巢癌关系研究进展[J].国际妇产科学杂志,2017,44(5):494-498,5.基金项目
贵州省卫生和计划生育委员会基金(gzwj2015-1-004) （gzwj2015-1-004）
