国际妇产科学杂志2017，Vol.44Issue(5)：535-538,4.
滋养细胞凋亡的二阶段与子痫前期二阶段发病机制关系的探讨
The Relationship between Two Phase Apoptosis of Trophoblast and Two Phase Pathogenesis of Preeclampsia
摘要
Abstract
Preeclampsia is a serve obstetric complication, which not only affects maternal health, but also influences the long-term prognosis of their offspring. The etiology and pathogenesis have not been fully understood. Preeclampsia is a placenta source disease, its development can be divided into two stages. The first stage for the forming process of pathophysiological changes which is characterized with abnormal extravillous trophoblast invasion, impaired spiral artery remodeling and reduced placental perfusion. The second stage for organ damage which cause a variety of clinical manifestations. Apoptosis of villous trophoblast plays an important role on the pathogenesis of preeclampsia, apoptosis imbalance can lead to the abnormal invasion ability. At different stage of the disease, apoptosis mechanism of the villous trophoblast is also different. Summarizes the literature found that first stage maily for the decidual killer cells induce excessive extravillous trophoblast apoptosis which causes impaired spiral artery remodeling, the second stage of the abnormal structure of spiral arteries which causes ischemia and hypoxia of placenta resulted in excessive syncytiotrophoblast apoptosis. But the related mechanism needs further research.关键词
先兆子痫/滋养层/胎盘/细胞凋亡/杀伤细胞,天然/蜕膜自然杀伤细胞Key words
Pre-eclampsia/Trophoblasts/Placenta/Apoptosis/Killer cells,natural/Decidual NK cell引用本文复制引用
徐欣然,陈叙,崔洪艳,贾艳菊..滋养细胞凋亡的二阶段与子痫前期二阶段发病机制关系的探讨[J].国际妇产科学杂志,2017,44(5):535-538,4.
