国际妇产科学杂志2017，Vol.44Issue(5)：589-593,5.
盆底功能障碍性疾病基础研究进展
Advance on the Pathogenesis of Female Pelvic Floor Dysfunction
摘要
Abstract
Female pelvic floor dysfunction (FPFD) is one of the most common chronic diseases affecting women′s health in our country, with primary clinical manifestations of pelvic organ prolapse (POP) and stress urinary incontinence (SUI). Currently, basic and clinical studies suggest that pelvic floor muscle damage and abnormal metabolism of protein in pelvic floor supportive tissue are the major pathogenesis of FPFD. On the one hand, pelvic floor muscle damage is mainly caused by pregnancy and menopause. On the other hand, the abnormal metabolism of collagen is associated with transforming growth factorβ(TGF-β), decorin (DN), matrix metalloproteinases (MMPs) and their antagonists (TIMPs). Besides, lysyl oxidase (LOX) and Fubilin protein are relative to the abnormal metabolism of elastin. In this paper, related risk factors of pelvic floor muscle damage and factor regulation of pelvic floor supportive tissue are discussed, hoping to deepen the pathogenesis of female pelvic floor dysfunction and provide information for its clinical therapy.关键词
盆底功能障碍性疾病/盆底肌/蛋白代谢/激素/骨盆底/脱垂/尿失禁,压力性/肌张力Key words
Female pelvic floor dysfunction/Pelvic floor muscle/Proteometabolism/Hormone/Pelvic floor/Prolapse/Urinary incontinence,stress/Muscle tonus引用本文复制引用
陈锐娥,周幸知,丁淼,陈劲,谢昕,林仲秋,陈美婉..盆底功能障碍性疾病基础研究进展[J].国际妇产科学杂志,2017,44(5):589-593,5.基金项目
澳门大学研究基金(MYRG2016-00130-ICMS-QRCM) （MYRG2016-00130-ICMS-QRCM）
