广西医学2017，Vol.39Issue(10)：1490-1493,1511,5.DOI:10.11675/j.issn.0253-4304.2017.10.09
乳腺导管原位癌伴微浸润的临床病理特征及危险因素
Clinicopathological features and risk factors of breast ductal carcinoma in situ complicated with microinvasion
摘要
Abstract
Objective To explore the clinicopathological features and risk factors of breast ductal carcinoma in situ with microinvasion (DCIS-Mi).Methods A total of 141 female patients with breast cancer were enrolled .All patients were divided into DCIS group (n=584) and DCIS-Mi group(n=83) according to the postoperatively pathological results .The general data,peripheral hematological indexes,therapeutic regimen and pathological features were compared between the two groups ,and the logistic regression model was used to analyze the factors influencing the incidence of DCIS-Mi.Results The DCIS-Mi group obtained higher proportion of patients with palpable mass/menopause or patients without induced abortion history compared to the DCIS group ,and the PLT count,PLT-to-lymphocyte ratio, proportion of well-differentiated cases , negative rates of estrogen receptor and progesterone receptor , and proportion of patients with high expression of human epidermal growth factor receptor-2(HER2) or Ki-67 in the DCIS-Mi group were higher than those in the DCIS group (P<0.05).Modified radical mastectomy and chemotherapy were common in the DCIS-Mi group,while simplex mastectomy and endocrinotherapy in the DCIS group.The result of multivariate analysis showed that menopause and histological grade were independent factors influencing the incidence of DCIS-Mi(P<0.05).Conclusion Menopause and middle and senior histological grade may be the risk factors for the incidence of DCIS-Mi.关键词
乳腺导管原位癌/微浸润/临床特征/病理特征/危险因素/绝经/肿瘤组织学分级Key words
Breast ductal carcinoma in situ/Microinvasion/Clinical feature/Pathological feature/Risk factor/Menopause/Histological grade of tumor分类
医药卫生引用本文复制引用
汪雯洁,丁小军,王敏,焦武,魏路,姚峰..乳腺导管原位癌伴微浸润的临床病理特征及危险因素[J].广西医学,2017,39(10):1490-1493,1511,5.基金项目
湖北省计生委基金项目( JS-2011019 ) （ JS-2011019 ）
