广西医学2017，Vol.39Issue(10)：1542-1545,4.DOI:10.11675/j.issn.0253-4304.2017.10.24
俞原配穴针刺对慢性心肌缺血大鼠的保护作用及其机制研究
Protective effects of combined acupuncture at transport and source acupoints on rats with chronic myocardial ischemia and its mechanism
摘要
Abstract
Objective To investigate the protective effects of combined acupuncture at transport and source acupoints on rats with chronic myocardial ischemia and its mechanism .Methods Forty-eight Wistar rats were randomly divided into control group ,model group , combined acupoint group and single acupoint group ,with 12 cases in each group .The chronic myocardial ischemia model was developed by injection with isoprenaline hydrochloride in each group except the control group .After the successful modeling , the rats in the combined acupoint group were acupunctured at Shenmen ,Daling,Xinshu and Queyinshu acupoints ,while the rats in the single acupoint group were only acupunctured at Neiguan acupoint .And no intervention was performed in the control group or the model group .The cardiac function indexes including left ventricular systolic pressure ( LVSP ) , left ventricular end-diastolic pressure ( LVEDP ) , maximum velocity of left ventricular pressure rise( +dp/dtmax),maximum velocity of left ventricular pressure fall ( -dp/dtmax),and heart rate were compared among all groups.The changes in the levels of serum superoxide dismutase (SOD),malonaldehyde(MDA),lipid peroxidation(LPO) and glutathione peroxidase(GSH-PX),as well as myocardial infarct sizes were observed in each group .Results Compared to the model group,LVSP,+dp/dtmax ,-dp/dtmax ,heart rate,SOD and GSH-PX levels were higher while MDA and LPO levels and LVEDP were lower in the combined acupoint group(all P<0.05) after 15 days of intervention.Compared to the single acupoint group,LVSP,+dp/dtmax ,-dp/dtmax , SOD and GSH-PX levels were higher while LPO level was lower in the combined acupoint group(all P<0.05).The myocardial infarct size in the combined acupoint group was less than that in the model group or the single acupoint group(all P<0.05).Conclusion Combined acupuncture at transport and source acupoints has protective effects on rats with chronic myocardial ischemia ,and its mechanism may correlate with the role of the combined acupuncture in alleviating lipid peroxidation damage and reducing the severity of myocardial injury .关键词
慢性心肌缺血/俞原配穴/针刺疗法/盐酸异丙肾上腺素/大鼠Key words
Chronic myocardial ischemia/Transport-source acupoint combination/Acupuncture therapy/Hydrochloride isoprenaline/Rat俞原配穴法是依据中医基础理论/在整体观念与辨分类
医药卫生引用本文复制引用
温勇,尹家琛,李燕婧..俞原配穴针刺对慢性心肌缺血大鼠的保护作用及其机制研究[J].广西医学,2017,39(10):1542-1545,4.基金项目
广西医疗卫生适宜技术研究与开发课题( S201409-02 ) （ S201409-02 ）
