湖南中医药大学学报2017，Vol.37Issue(10)：1074-1077,4.DOI:10.3969/j.issn.1674-070X.2017.010.006
不同芍药甘草配伍用于溃疡性结肠炎的治疗作用及机制研究
Study on Therapeutic Effect and Mechanism of Different Compatibility of Peony and Licorice on Ulcerative Colitis
摘要
Abstract
Objective To study the therapeutic effect and mechanism of different compatibility of peony and licorice on ulcerative colitis (UC). Methods The 90 experimental mice were randomly divided into the No. 1 observation group, No. 2 observation group, and control group, 30 mice in each group. The UC model mice of the No. 1 observation group and No. 2 observation group were built by the acetic acid method, intervened with interved peony Licorice decoction, the compatibility of peony and licorice with 3:1 and 1:1 in the two groups. The control group was fed normally without other interventions. The thymus spleen index and colonic tissue nuclear factor-kBp65 (NF-kBp65) were recorded in three groups, the colonic contraction fre quency, writhing, inflammatory cell number, size, density and average total blackness between No. 1 observation group and No. 2 observation group were observed. Results The colonic contraction frequency and writhing frequency in No. 1 observa-tion group after giving medicine for 30 minutes and 1 hour were lower than the control group and before drug administration (P<0.05). The thymus and spleen indexes in No.1 observation group were higher than that in the No.2 observation group, and colon tissue NF-kBp65 was lower than the No.2 observation group (P<0.05). The number of inflammatory cells, inflammatory cell area, the average optical density and the average total blackness of the No.1 observation group were significantly lower than those in No.2 observation group (P<0.05). Conclusion The 3:1 proportion of peony and licorice are more effective in im-proving the pain and diarrhea than 1:1 ratio in the treatment for UC. This may be related to controlling inflammatory infiltra-tion, stimulating immune organ secreting immune cells and inhibiting NF-kB activation.关键词
芍药/甘草/溃疡性结肠炎Key words
peony/licorice/ulcerative colitis分类
医药卫生引用本文复制引用
陈晓峰,谢君..不同芍药甘草配伍用于溃疡性结肠炎的治疗作用及机制研究[J].湖南中医药大学学报,2017,37(10):1074-1077,4.基金项目
江苏省自然科学基金计划(815269). （815269）
