检验医学与临床2017，Vol.14Issue(18)：2662-2663,2666,3.DOI:10.3969/j.issn.1672-9455.2017.18.003
1％七氟醚复合异丙酚对老年患者肠道手术后认知功能的影响
The effect of 1％ sevoflurane combined with propofol on cognitive function in aged patients after intestinal surgery
摘要
Abstract
Objective To investigate the effects of 1 ％ sevoflurane combined with propofol on cognitive function in aged patients after intestinal surgery.Methods 60 patients(ASA Ⅰ or Ⅱ) underwent open resection of rectum and colon cancer,aged 65 to 77 years old,excluding preoperative cognitive dysfunction or recognized factors affecting cognitive function,were randomly divided into sevoflurane combined with propofol group(M),sevoflurane group (S) and propofol group (P).Patients in group M were received 1％ sevoflurane and propofol to maintain anesthesia,patients in group S were inhaled sevoflurane,the others in group P were infused propofol.At preoperative and postoperative 1 h,6 h,1 d,3 d and 7 d,the patients were used to evaluate the cognitive function of patients with MMSE score.Spontaneous breathing recovery time,extubation time,and called the open-eyes time were recorded.Results Compared with preoperative,MMSE score at postoperative 1 h were decreased (P＜0.05).At postoperative 1 h,MMSE score in group S was lower than the others (P＜0.05).At postoperative 6 h,MMSE score were recovered,but had not yet returned to preoperative levels (P＜0.05).At postoperative 1 d,3 d,7 d,there were no significant difference in MMSE score among three groups.Conclusion 1％ sevoflurane combined with propofol is used in aged patients,who have underwent intestinal surgery,does not increase the incidence of postoperative cognitive dysfunction.关键词
七氟醚/异丙酚/胃肠道/老年人/认知障碍Key words
anesthetics,inhalation/propofol/gastrointestinal tract/aged/cognition disorders引用本文复制引用
石海霞,胡雅娟,于建设..1％七氟醚复合异丙酚对老年患者肠道手术后认知功能的影响[J].检验医学与临床,2017,14(18):2662-2663,2666,3.基金项目
内蒙古自治区卫生厅课题(201302060). （201302060）
