检验医学与临床2017，Vol.14Issue(18)：2673-2675,3.DOI:10.3969/j.issn.1672-9455.2017.18.007
CD64指数在手足口病并发病毒性脑炎和化脓性脑膜炎中鉴别诊断的价值
The value of CD64 index in hand foot mouth disease complicated with viral encephalitis and purulent meningitis
摘要
Abstract
Objective To explore the application value of CD64 expression on the neutrophils in the identification of children with hand,foot and mouth disease complicated by viral encephalitis (HFMD-encephalitis) and purulent meningitis.Methods The expression of CD64 on the membrane of neutrophils was measured by flow cytometry,and the CD64 index was calculated.AVOVA was used to compare the expression of CD64 in the neutrophils of children with HFMD-encephalitis,purulent meningitis and controls.The diagnostic efficacies of CD64 indexand CRP in diagnosis of purulent meningitis were compared by ROC curve.Results The expression of CD64 on the neutrophils had significant difference in children with HFMD-encephalitis,purulent meningitis and controls (P＜0.01).ROC curve analysis showed that the CD64 index with cut-off 0.17 has higher sensitivity and specificity than CRP.Conclusion The CD64 index has important value in the diagnosis of HFMD-encephalitis and purulent meningitis.关键词
CD64指数/手足口病/病毒性脑炎/化脓性脑膜炎Key words
CD64 index/hand,foot and mouth disease/viral encephalitis/purulent meningitis引用本文复制引用
方代华,邓罗华,刘洋,孙浩淼,邓星强..CD64指数在手足口病并发病毒性脑炎和化脓性脑膜炎中鉴别诊断的价值[J].检验医学与临床,2017,14(18):2673-2675,3.基金项目
江苏省徐州市科技局资助项目(XZZD1368). （XZZD1368）
