检验医学与临床2017，Vol.14Issue(18)：2689-2691,3.DOI:10.3969/j.issn.1672-9455.2017.18.013
急性髓系白血病伴骨髓增殖异常相关改变的形态学及染色体核型研究
The characteristic of acute myeloid leukemia with myelodysplastic related changes about the karyotype and morphology
摘要
Abstract
Objective Aim to research the characteristic of acute myeloid leukemia with myelodysplastic related changes to improve the diagnosis in clinical.Methods 281 patients surfing from AML divided into 5 groups,including AML-M2,AML-M4,AML -M5,AML-M6 and AML-MRC.The quantity,morphology and the karyotype of the bone marrow cells were analyzed.And then Statistics analyzed by SPSS19.0 The Tunnett C in each group.Results The number of blasts:M2(99.700+36.109),M4(110.260±40.234),M5(159.770±29.215),M6(35.050± 19.701),MRC(59.390 ± 17.944).Compared to the groups,the variance analysis showed the F value 121.456(P＜0.001).It meant the number of blasts of AML-M6＜ the ones of AML-MRC＜ the ones of AMLM2/4/5.The number of erythroblasts:M2 (16.660 ± 17.165),M4 (14.150 ± 14.643),M5 (9.090 ± 10.619),M6 (126.310 ± 27.750),MRC(47.430± 21.209).Compared to the groups,the variance analysis showed the F value 309.407 (P＜0.001).And it meant the number of erythroblasts of AML-M6＜ the ones of AML-MRC＜ the ones of AML M2/4/5 in contrary.Then the dysplastic include Pseudo-Pelger-Hu(e)t cells,absence of granules,abnormal segmentation of cells,red cell with abnormal chromatin clumping (nuclear budding,internuclear bridging,karyorrhexis,multinuclearity).The frequency of them were different in AMLMRC and AML-2/4/5/6.Karyotype analysis showed 58.8％ (20/34)abnormality in AML-MRC,including 14 MDS related karyotype (-7/del(7q),-5/del(5q),+8),and 6 others changes.Conclusion (1)Not all karyotype can be in AML-MRC.(2)The morphological characteristic of AML-MRC:The blasts are slightly higher than 20 ％.The erythroid is uninhibited.(3)Dysplastic shows the different in AML-MRC.It means the part of them could be the powerful dependence of the diagnosis in AML-MRC.关键词
白血病/病态造血/核型Key words
acute myeloid leukemia/dysplastic/karyotype引用本文复制引用
李佳,杨武晨,杨程,唐永杰,王平,邓小娟,彭贤贵,墙星,张曦,刘思恒,冉岑霞,张洪洋,陶廷露,陈思宇,苟阳..急性髓系白血病伴骨髓增殖异常相关改变的形态学及染色体核型研究[J].检验医学与临床,2017,14(18):2689-2691,3.基金项目
重庆市社会事业与民生保障科技创新专项项目(cstc2016shrns-ztzxl003). （cstc2016shrns-ztzxl003）
