内科理论与实践2017，Vol.12Issue(4)：262-268,7.DOI:10.16138/j.1673-6087.2017.04.007
脂联素、瘦素和肿瘤坏死因子-α与酒精性脂肪肝严重程度的相关性
The association of adiponectin, leptin and tumor necrosis factor-α with severity of alcoholic fatty liver
摘要
Abstract
Objective To study the association of adiponectin,leptin and tumor necrosis factor-α (TNF-α) with severity of alcoholic fatty liver.Methods Forty-five Wistar rats were divided into control,ethanol-fed and betaine-fed groups.Hepatic triglyceride was measured by enzymatic colorimetric method.Adiponectin,leptin and TNF-α levels were determined by enzyme-linked immunosorbent assay.Pearson correlation analysis and multivariable linear-regression analysis were used to detect the association between these factors and alcoholic fatty liver.Results Ethanol resulted in increased triglyceride content in liver,reduced adiponectin and increased leptin in serum and liver.Compared with ethanol group,betaine reduced hepatic triglyceride,up-regulated serum and hepatic adiponectin,but did not affect leptin in liver and serum.There was no significant difference in hepatic TNF-α among these three groups.Serum adiponectin was negatively correlated with triglyceride content in liver (r=-0.605,P=0.000).Serum leptin,liver adiponectin and leptin were not the independent influencing factors of triglyceride content in liver.Conclusions Serum adiponectin was an important predictor of severity of alcoholic fatty liver,increasing serum adiponectin might reduce the triglyceride content in liver.Leptin and TNF-α did not correlate independently with alcoholic fatty liver.关键词
脂联素/瘦素/肿瘤坏死因子-α/三酰甘油/酒精性脂肪肝Key words
Adiponectin/Leptin/Tumor necrosis factor-α/Triglyceride/Alcoholic fatty liver分类
医药卫生引用本文复制引用
杨文娟,黄志寅,唐承薇,李静..脂联素、瘦素和肿瘤坏死因子-α与酒精性脂肪肝严重程度的相关性[J].内科理论与实践,2017,12(4):262-268,7.基金项目
国家自然科学基金项目(项目编号:81170384) （项目编号:81170384）
