内科理论与实践2017，Vol.12Issue(4)：269-273,5.DOI:10.16138/j.1673-6087.2017.04.008
血清不对称二甲基精氨酸在肥胖糖耐量异常患者大血管病变中的意义
The significance of serum asymmetric dimethylarginine level on macrovascular disease in patients with impaired glucose tolerance
摘要
Abstract
Objective To investigate the significance of serum asymmetric dimethylarginine(ADMA),adiponectin(APN) and C-reactive protein(CRP) level on macrovascular complication in obese impaired glucose tolerance(IGT) patients.Methods Patients were divided into 3 groups:43 patients with normal glucose tolerance(NGT),48 non-obese patients with impaired glucose tolerance (IGT-nob),and 47 obese patients with IGT(IGT-ob).Body mass index (BMI),blood pressure,blood lipid,insulin,ADMA,APN,CRP and carotid intima-media thickness (CIMT) were measured.The data of these parameters were compared and their correlations were analyzed.Results The BMI in IGT-ob group was significantly higher than those in IGTnob and NGT groups(P=0.000).Fasting plasma glucose(FPG),2-hour postprandial plasma glucose in both IGT-ob and IGT-nob groups were significantly higher than those in NGT group(P＜0.05);fasting insulin(FINS),homeostasis model assessment-insulin resistance(HOMA-IR) in IGT-nob and NGT groups were significantly lower than that in IGT-ob group(P=0.000).APN in IGT-nob and NGT groups were significantly higher than that in IGT-ob group (P＜0.05),ADMA,CRP in IGT-nob and NGT groups were significantly lower than that in IGT-ob group (P＜0.05),CIMT in NGT group was lower than that in IGT-nob and IGT-ob groups(P＜0.05).ADMA,CRP in IGT-nob group were higher than that in NGT group (P＜0.05).CIMT in IGT-nob was lower than that in IGT-ob group (P=0.016).Multivariate regression analysis showed that ADMA,APN and HOMA-IR were independently correlated with BMI,and ADMA,CRP and BMI were independently correlated with CIMT.Conclusions ADMA could be a predictive factor of IGT patients with macrovascular complication,especially in obese IGT patients.关键词
糖耐量异常/不对称二甲基精氨酸/脂联素/C反应蛋白/颈静脉内膜中层厚度Key words
Impaired glucose tolerance/Asymmetric dimethylarginine/Adiponectin/C-reactive protein/Carotid intima-media thickness分类
医药卫生引用本文复制引用
汤瑜斌,彭文芳,夏莉莉,黄珊..血清不对称二甲基精氨酸在肥胖糖耐量异常患者大血管病变中的意义[J].内科理论与实践,2017,12(4):269-273,5.基金项目
上海市卫生局科研课题(项目编号:20124248) （项目编号:20124248）
长宁区科学技术委员会重点项目(项目编号:CNKW2016Z03) （项目编号:CNKW2016Z03）
