实用肿瘤杂志2017，Vol.32Issue(5)：416-420,5.
结直肠癌脑转移的临床特点和预后
Clinical characteristics and prognosis of brain metastasis in colorectal cancer
摘要
Abstract
Objective To analyze the clinical characteristics and prognosis of brain metastasis (BM) in patients with colorectal carcinoma (CRC).Methods Total 1 714 cases of colorectal cancer were collected and patients with BM were screened.Clinical data of 36 CRC cases with BM were retrospectively analyzed.Results In all screened CRC patients,those with BM accounted for 2.1％ (36/1 714),which represented 3.3％ of BM patients during the study time period.Among 36 cases,there were 21 males (58.3％),19 cases of rectal cancer (52.8％) and 32 cases of stage Ⅲ and Ⅳ (88.9％).Staging was an independent factor of brain-metastasis-free survival (HR =2.072,P =0.042).Moreover,55.6％ of patients (20/36) had single BM lesion,and 94.4％ of patients (34/36) also had extracranial metastases,of which lung was the most common metastatic organ (22/36,61.1％).The median post-brain-metastasis suvival (PBMS) times for patients with recursive partitioning analysis (RPA) class Ⅰ,Ⅱ and Ⅲ were not reached,17 months and 3 months,respectively (P =0.002).Multivariate analysis showed that Karnofsky performance status (KPS) score of patients upon the identification of BM was an independent prognostic factor of PBMS (HR =8.797,P =0.044).However,post-BM radiation therapy and/or chemotherapy were not found to improve patients' prognosis.Conclusion The incidence of BM is low in CRC patients.RPA is a valuable prognostic index.Post-BM radiotherapy and/or chemotherapy may have no effect on improving prognosis.关键词
结直肠肿瘤/外科学/脑肿瘤/外科学/脑肿瘤/继发性/肿瘤转移/放射疗法/药物疗法/回顾性研究/随访研究Key words
colorectal neoplasms/surgery/brain neoplasms/surgery/brain neoplasms/secondary/neoplasm metastasis/radiotherapy/drug therapy/retrospective studies/follow-up studies分类
医药卫生引用本文复制引用
李博,白日星,李有国,邱晓光..结直肠癌脑转移的临床特点和预后[J].实用肿瘤杂志,2017,32(5):416-420,5.基金项目
首都卫生发展专项基金(2014-4-5082) （2014-4-5082）
北京市博士后科研工作经费 （）
