天然产物研究与开发2017，Vol.29Issue(9)：1542-1545,1594,5.DOI:10.16333/j.1001-6880.2017.9.015
连翘提取物和连翘挥发油对酵母致热大鼠的解热机制研究
Antipyretic Effect of Forsythia suspense Extract and Forsythia Oil on Yeast-induced Fever Rats and Its Mechanism
摘要
Abstract
Antipyretic effect and mechanisms of Forsythia suspensa extract and forsythia oil on rats with high fever induced by yeast were investigated in the study.Rat model of yeast-induced fever was established by subcutaneous injections of yeast.After the basal body temperature was measured,the rats were randomly divided into four groups:control group,model group,Forsythia extract group (25 crude drug g/kg) andforsythia oil group (26.7 crude g/kg).Then the body temperature and the concentration of prostaglandin E2 (PGE2) and cyclic adenosine monophosphate (cAMP) in the hypothalamus cerebrospinal fluid of rats were detected dynamically two hours after dosing.The result showed that F.suspensa extract and forsythia oilcan significantly decrease the temperature(P ＜0.01 or P ＜0.05)as well as hypothalamus cAMP content(P ＜ 0.01) in yeast-induced fever rats.In addition,F.suspensa extract also obviously decreased hypothalamus PGE2content (P ＜0.01).F.suspensa extract can down-regulate cAMP and PGE2 in hypothalamus.And forsythia oil down-regulatecAMP in hypothalamus.Both can be used as symptomatic treatment for clinical fever.关键词
解热/连翘提取物/连翘挥发油/下丘脑cAMP/PGE2Key words
Forsythia suspensa extract/forsythia oil/antipyretic mechanism/cAMP/PGE2分类
医药卫生引用本文复制引用
党珏,袁岸,罗林,全云云,赵梦杰,李芸霞..连翘提取物和连翘挥发油对酵母致热大鼠的解热机制研究[J].天然产物研究与开发,2017,29(9):1542-1545,1594,5.基金项目
国家自然科学基金(81373943,81573583) （81373943,81573583）
四川省杰出青年基金(2013JQ0018) （2013JQ0018）
四川省科技厅省青年科技创新研究团队专项计划项目(2017TD0001,2015TD0028,2016TD0006) （2017TD0001,2015TD0028,2016TD0006）
成都中医药大学科技发展基金(ZRYB201425) （ZRYB201425）
