天然产物研究与开发2017，Vol.29Issue(9)：1568-1572,5.DOI:10.16333/j.1001-6880.2017.9.020
绿茶多酚对兔主动脉粥样硬化斑块中磷酸化p38MAPK的影响
Effect of Green Tea Polyphenols on Phosphorylated p38MAPK in Experimental Atherosclerosis Rabbits
摘要
Abstract
To investigate the effect of green tea polyphenols (GTP) on phosphorylated p38MAPK in experimental atherosclerosis (AS) rabbits.Pure healthy male New Zealand white rabbits were randomly divided into 3 groups:Control group:feeding ordinary granulated feed;AS group:high-fat diet combined immune injury;GTP + AS group:in addition to the high-fat diet combined immune injury,green tea polyphenol was given 100 mg/kg · d.Histopathology and vascular ultrasound examination were used to evaluate AS in experimental rabbits.Western blot was used to detect the expression of phosphorylated p38MAPK (p-p38MAPK),and enzyme-linked immunosorbent assay was used to determine the secretion of TNF-α in experimental rabbits.Compared with control group,the level of TNF-α and p-p38MAPK were significantly increased (P ＜ 0.01).After giving GTP,the level of TNF-α and p-p38MAPK were significantly decreased (P ＜ 0.01).GTP can delay AS plaque progression and suppresses inflammation,these effects were possibly related to inhibit p38MAPK signal pathway activation.关键词
绿茶多酚/动脉粥样硬化/p38MAPK/信号传导Key words
GTP/atherosclerosis/p38MAPK/signal transduction分类
医药卫生引用本文复制引用
刘洪,唐旭,汤志梅,唐曦..绿茶多酚对兔主动脉粥样硬化斑块中磷酸化p38MAPK的影响[J].天然产物研究与开发,2017,29(9):1568-1572,5.基金项目
四川省教育厅科研项目资助课题(15ZB0251) （15ZB0251）
四川省卫生科研项目资助课题(120472) （120472）
